{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["65"],"submitter":["Huang Q"],"pubmed_abstract":["<h4>Introduction</h4>Ginsenosides (GS) derived from Panax ginseng can regulate protein acetylation to promote mitochondrial function for protecting cardiomyocytes. However, the potential mechanisms of GS for regulating acetylation modification are not yet clear.<h4>Objectives</h4>This study aimed to explore the potential mechanisms of GS in regulating protein acetylation and identify ginsenoside monomer for fighting myocardial ischemia-related diseases.<h4>Methods</h4>The 4D-lable free acetylomic analysis was employed to gain the acetylated proteins regulated by GS pretreatment. The co-immunoprecipitation assay, immunofluorescent staining, and mitochondrial respiration measurement were performed to detect the effect of GS or ginsenoside monomer on acetylated protein level and mitochondrial"],"journal":["Journal of advanced research"],"pagination":["365-379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11518965"],"repository":["biostudies-literature"],"pubmed_title":["Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic/reperfusion injury."],"pmcid":["PMC11518965"],"pubmed_authors":["Wu M","Li J","Chen J","Tong X","Huang Q","Yang W","Li X","Yao Y","Zhao L","Guo C","Zhao D","Wang Y","Lou J"],"additional_accession":[]},"is_claimable":false,"name":"Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic/reperfusion injury.","description":"<h4>Introduction</h4>Ginsenosides (GS) derived from Panax ginseng can regulate protein acetylation to promote mitochondrial function for protecting cardiomyocytes. However, the potential mechanisms of GS for regulating acetylation modification are not yet clear.<h4>Objectives</h4>This study aimed to explore the potential mechanisms of GS in regulating protein acetylation and identify ginsenoside monomer for fighting myocardial ischemia-related diseases.<h4>Methods</h4>The 4D-lable free acetylomic analysis was employed to gain the acetylated proteins regulated by GS pretreatment. The co-immunoprecipitation assay, immunofluorescent staining, and mitochondrial respiration measurement were performed to detect the effect of GS or ginsenoside monomer on acetylated protein level and mitochondrial","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-15T17:41:03.014Z","creation":"2025-04-04T13:20:02.639Z"},"accession":"S-EPMC11518965","cross_references":{"pubmed":["38101749"],"doi":["10.1016/j.jare.2023.12.012"]}}