{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He W"],"funding":["National Natural Science Foundation of China"],"pagination":["2921-2931"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519176"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(8)"],"pubmed_abstract":["<h4>Purpose</h4>This study aims to evaluate a combined effect of dietary folic acid intake, multiple genetic polymorphisms in folate metabolism, and other environmental factors on red blood cell (RBC) folate concentration in pregnancy-preparing population.<h4>Methods</h4>519 pregnancy-preparing subjects (260 couples) were investigated. Dietary intake was measured by 3-day dietary recalls. 13 Single Nucleotide polymorphisms (SNPs) reported in association with one-carbon metabolism including the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C were genotyped. RBC folate concentration was measured using chemiluminescence assay. Hierarchical regression was applied for covariate selection. Factors showed significance(p < 0.0125) on RBC folate level was included for prediction model "],"journal":["European journal of nutrition"],"pubmed_title":["Dietary folic acid intake, 13 genetic variants and other factors with red blood cell folate concentration in pregnancy-preparing population."],"pmcid":["PMC11519176"],"funding_grant_id":["82373584","82070323"],"pubmed_authors":["Dou Y","He Y","He W","Zhang Y","Chen X","Yan W"],"additional_accession":[]},"is_claimable":false,"name":"Dietary folic acid intake, 13 genetic variants and other factors with red blood cell folate concentration in pregnancy-preparing population.","description":"<h4>Purpose</h4>This study aims to evaluate a combined effect of dietary folic acid intake, multiple genetic polymorphisms in folate metabolism, and other environmental factors on red blood cell (RBC) folate concentration in pregnancy-preparing population.<h4>Methods</h4>519 pregnancy-preparing subjects (260 couples) were investigated. Dietary intake was measured by 3-day dietary recalls. 13 Single Nucleotide polymorphisms (SNPs) reported in association with one-carbon metabolism including the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C were genotyped. RBC folate concentration was measured using chemiluminescence assay. Hierarchical regression was applied for covariate selection. Factors showed significance(p < 0.0125) on RBC folate level was included for prediction model ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-07-15T17:37:58.284Z","creation":"2025-04-04T00:26:34.999Z"},"accession":"S-EPMC11519176","cross_references":{"pubmed":["39153125"],"doi":["10.1007/s00394-024-03474-z"]}}