{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang P"],"funding":["the Open Project of state key laboratory of military stomatology","National Natural Science Foundation of China"],"pagination":["66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519219"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(1)"],"pubmed_abstract":["An acellular bovine bone matrix modified to release Magnesium ions (Mg<sup>2+</sup>) (ABBM-Mg) was prepared and evaluated for its potential in osteogenesis and mandibular defect repair. Mg<sup>2+</sup> was incorporated into ABBM using an ion exchange method. The microstructure and mechanical properties of both ABBM and ABBM-Mg were analyzed using SEM and a biomechanical testing machine. Cytocompatibility, cell adhesion, and osteogenic differentiation were assessed using various methods including CCK-8, Live/Dead staining, SEM, ALP staining, and qPCR analysis in MC3T3-E1 cells. Additionally, a mandibular defect model in rats was established. The bone defect repair outcomes were evaluated using Micro-CT, histological HE staining, and Masson staining. The study showed that mineralization cont"],"journal":["Journal of materials science. Materials in medicine"],"pubmed_title":["Enhancing osteogenesis and mandibular defect repair with magnesium-modified acellular bovine bone matrix."],"pmcid":["PMC11519219"],"funding_grant_id":["82204820","2019KA01, 2019KB01"],"pubmed_authors":["Ge R","Wang P","Han L","Hu X","Li B","Li L","Xu G","Yu K"],"additional_accession":[]},"is_claimable":false,"name":"Enhancing osteogenesis and mandibular defect repair with magnesium-modified acellular bovine bone matrix.","description":"An acellular bovine bone matrix modified to release Magnesium ions (Mg<sup>2+</sup>) (ABBM-Mg) was prepared and evaluated for its potential in osteogenesis and mandibular defect repair. Mg<sup>2+</sup> was incorporated into ABBM using an ion exchange method. The microstructure and mechanical properties of both ABBM and ABBM-Mg were analyzed using SEM and a biomechanical testing machine. Cytocompatibility, cell adhesion, and osteogenic differentiation were assessed using various methods including CCK-8, Live/Dead staining, SEM, ALP staining, and qPCR analysis in MC3T3-E1 cells. Additionally, a mandibular defect model in rats was established. The bone defect repair outcomes were evaluated using Micro-CT, histological HE staining, and Masson staining. The study showed that mineralization cont","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T01:08:43.078Z","creation":"2025-04-04T01:08:43.078Z"},"accession":"S-EPMC11519219","cross_references":{"pubmed":["39466468"],"doi":["10.1007/s10856-024-06835-6"]}}