{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["67(11)"],"submitter":["Masalin S"],"funding":["University of Helsinki","Suomen Kulttuurirahasto","Biomedicum Helsinki-säätiö","Päivikki ja Sakari Sohlbergin Säätiö","South Karelia medical association","Research Foundation for Obstetrics and Gynecology","Viipuri Tuberculosis Foundation","Jalmari ja Rauha Ahokkaan Säätiö","Juho Vainion Säätiö","Maud Kuistilan Muistosäätiö","Paulon Säätiö","Finska Läkaresällskapet","Research Foundation of South Karelia Central Hospital","Finnish State Funding for University-level Health Research","Diabetestutkimussäätiö"],"pubmed_abstract":["<h4>Aims/hypothesis</h4>It is not known whether the early-pregnancy metabolome differs in patients with early- vs late-onset gestational diabetes mellitus (GDM) stratified by maternal overweight. The aims of this study were to analyse correlations between early-pregnancy metabolites and maternal glycaemic and anthropometric characteristics, and to identify early-pregnancy metabolomic alterations that characterise lean women (BMI <25 kg/m<sup>2</sup>) and women with overweight (BMI ≥25 kg/m<sup>2</sup>) with early-onset GDM (E-GDM) or late-onset GDM (L-GDM).<h4>Methods</h4>We performed a nested case-control study within the population-based prospective Early Diagnosis of Diabetes in Pregnancy cohort, comprising 210 participants with GDM (126 early-onset, 84 late-onset) and 209 normoglycaemi"],"journal":["Diabetologia"],"pagination":["2539-2554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519293"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight."],"pmcid":["PMC11519293"],"pubmed_authors":["Klavus A","Rono K","Koistinen V","Karkkainen O","Klemetti MM","Koistinen HA","Masalin S","Jaaskelainen TJ"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight.","description":"<h4>Aims/hypothesis</h4>It is not known whether the early-pregnancy metabolome differs in patients with early- vs late-onset gestational diabetes mellitus (GDM) stratified by maternal overweight. The aims of this study were to analyse correlations between early-pregnancy metabolites and maternal glycaemic and anthropometric characteristics, and to identify early-pregnancy metabolomic alterations that characterise lean women (BMI <25 kg/m<sup>2</sup>) and women with overweight (BMI ≥25 kg/m<sup>2</sup>) with early-onset GDM (E-GDM) or late-onset GDM (L-GDM).<h4>Methods</h4>We performed a nested case-control study within the population-based prospective Early Diagnosis of Diabetes in Pregnancy cohort, comprising 210 participants with GDM (126 early-onset, 84 late-onset) and 209 normoglycaemi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T01:58:39.56Z","creation":"2025-04-04T01:58:39.56Z"},"accession":"S-EPMC11519293","cross_references":{"pubmed":["39083240"],"doi":["10.1007/s00125-024-06237-x"]}}