biostudies-literatureUnknown67(11)Masalin SUniversity of HelsinkiSuomen KulttuurirahastoBiomedicum Helsinki-säätiöPäivikki ja Sakari Sohlbergin SäätiöSouth Karelia medical associationResearch Foundation for Obstetrics and GynecologyViipuri Tuberculosis FoundationJalmari ja Rauha Ahokkaan SäätiöJuho Vainion SäätiöMaud Kuistilan MuistosäätiöPaulon SäätiöFinska LäkaresällskapetResearch Foundation of South Karelia Central HospitalFinnish State Funding for University-level Health ResearchDiabetestutkimussäätiö<h4>Aims/hypothesis</h4>It is not known whether the early-pregnancy metabolome differs in patients with early- vs late-onset gestational diabetes mellitus (GDM) stratified by maternal overweight. The aims of this study were to analyse correlations between early-pregnancy metabolites and maternal glycaemic and anthropometric characteristics, and to identify early-pregnancy metabolomic alterations that characterise lean women (BMI <25 kg/m²) and women with overweight (BMI ≥25 kg/m²) with early-onset GDM (E-GDM) or late-onset GDM (L-GDM).<h4>Methods</h4>We performed a nested case-control study within the population-based prospective Early Diagnosis of Diabetes in Pregnancy cohort, comprising 210 participants with GDM (126 early-onset, 84 late-onset) and 209 normoglycaemiDiabetologia2539-2554https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519293biostudies-literatureAnalysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight.PMC11519293Klavus ARono KKoistinen VKarkkainen OKlemetti MMKoistinen HAMasalin SJaaskelainen TJfalseAnalysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight.<h4>Aims/hypothesis</h4>It is not known whether the early-pregnancy metabolome differs in patients with early- vs late-onset gestational diabetes mellitus (GDM) stratified by maternal overweight. The aims of this study were to analyse correlations between early-pregnancy metabolites and maternal glycaemic and anthropometric characteristics, and to identify early-pregnancy metabolomic alterations that characterise lean women (BMI <25 kg/m²) and women with overweight (BMI ≥25 kg/m²) with early-onset GDM (E-GDM) or late-onset GDM (L-GDM).<h4>Methods</h4>We performed a nested case-control study within the population-based prospective Early Diagnosis of Diabetes in Pregnancy cohort, comprising 210 participants with GDM (126 early-onset, 84 late-onset) and 209 normoglycaemi2024-01-01T00:00:00Z2024 Nov2025-04-04T01:58:39.56Z2025-04-04T01:58:39.56ZS-EPMC115192933908324010.1007/s00125-024-06237-x