{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lugon G"],"funding":["Agència de Gestió d'Ajuts Universitaris i de Recerca","Agència de Gestió d&apos;Ajuts Universitaris i de Recerca","'la Caixa' Foundation","‘la Caixa’ Foundation"],"pagination":["2885-2895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519306"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(8)"],"pubmed_abstract":["<h4>Background</h4>Our aim was to determine the association between diet quality and depression incidence in the population-based REGICOR cohort study, Catalonia, Spain.<h4>Methods</h4>Prospective observational study using participants' baseline (2003-2006), follow-up (2007-2013) and clinical records data. Five diet quality scores were derived from a food frequency questionnaire (FFQ) at baseline: the relative Mediterranean Diet Score (rMED), the Modified Mediterranean Diet Score (ModMDS), a Dietary Approaches to Stop Hypertension (DASH) score, a Healthful Plant-based Diet Index (HPDI) and the World Health Organization Healthy Diet Indicator (WHO-HDI). Participants using pharmacological antidepressant treatment were excluded as a proxy for presence of depression at baseline. At follow-up, the Patient Health Questionnaire (PHQ-9) was applied to assess depressive symptoms (≥ 10 defining depressive disorder). A secondary outcome was depression diagnosis assessed through clinical records. Logistic regression and Cox proportional hazards models were used.<h4>Results</h4>Main analysis included 3046 adults (50.3% women) with a mean age of 54.7 (SD = 11.6) years. After 6-years follow-up, 184 (6.04%) cases of depressive disorder were identified. There was 16% lower odds of depressive disorder per 1SD increase of rMED (OR = 0.84; 95%CI = 0.71-0.98). Secondary outcome analysis (n = 4789) identified 261 (5.45%) incident cases of clinical depression diagnosis over 12 years follow-up, and 19% lower risk of clinical depression was observed with the WHO-HDI (HR = 0.81; 95%CI = 0.70-0.93). Adjusting for BMI did not attenuate the findings.<h4>Conclusions</h4>A significant inverse association between diet quality and depression incidence was found in this population-based cohort study, independent of sociodemographic, health and lifestyle. Adherence to a healthy diet could be a complementary intervention for the prevention of depression."],"journal":["European journal of nutrition"],"pubmed_title":["Association between different diet quality scores and depression risk: the REGICOR population-based cohort study."],"pmcid":["PMC11519306"],"funding_grant_id":["PERIS SLT002/16/00088, PERIS STL006/17/00234, 2017SGR222","100010434"],"pubmed_authors":["Marrugat J","Lugon G","Jacka FN","Hernaez A","Garre-Olmo J","Ramos R","Elosua R","Lassale C"],"additional_accession":[]},"is_claimable":false,"name":"Association between different diet quality scores and depression risk: the REGICOR population-based cohort study.","description":"<h4>Background</h4>Our aim was to determine the association between diet quality and depression incidence in the population-based REGICOR cohort study, Catalonia, Spain.<h4>Methods</h4>Prospective observational study using participants' baseline (2003-2006), follow-up (2007-2013) and clinical records data. Five diet quality scores were derived from a food frequency questionnaire (FFQ) at baseline: the relative Mediterranean Diet Score (rMED), the Modified Mediterranean Diet Score (ModMDS), a Dietary Approaches to Stop Hypertension (DASH) score, a Healthful Plant-based Diet Index (HPDI) and the World Health Organization Healthy Diet Indicator (WHO-HDI). Participants using pharmacological antidepressant treatment were excluded as a proxy for presence of depression at baseline. At follow-up, the Patient Health Questionnaire (PHQ-9) was applied to assess depressive symptoms (≥ 10 defining depressive disorder). A secondary outcome was depression diagnosis assessed through clinical records. Logistic regression and Cox proportional hazards models were used.<h4>Results</h4>Main analysis included 3046 adults (50.3% women) with a mean age of 54.7 (SD = 11.6) years. After 6-years follow-up, 184 (6.04%) cases of depressive disorder were identified. There was 16% lower odds of depressive disorder per 1SD increase of rMED (OR = 0.84; 95%CI = 0.71-0.98). Secondary outcome analysis (n = 4789) identified 261 (5.45%) incident cases of clinical depression diagnosis over 12 years follow-up, and 19% lower risk of clinical depression was observed with the WHO-HDI (HR = 0.81; 95%CI = 0.70-0.93). Adjusting for BMI did not attenuate the findings.<h4>Conclusions</h4>A significant inverse association between diet quality and depression incidence was found in this population-based cohort study, independent of sociodemographic, health and lifestyle. Adherence to a healthy diet could be a complementary intervention for the prevention of depression.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-07-07T03:18:15.956Z","creation":"2025-04-04T13:19:29.774Z"},"accession":"S-EPMC11519306","cross_references":{"pubmed":["39180556"],"doi":["10.1007/s00394-024-03466-z"]}}