{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marshall KM"],"funding":["Medical Research Council","ERC proof of concept","National Institute for Health Research (NIHR)","UK Regenerative Medicine Platform","National Institute for Health and Care Research","Biotechnology and Biological Sciences Research Council"],"pagination":["25832"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519456"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Bone tissue engineering aims to harness materials to develop functional bone tissue to heal 'critical-sized' bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed to augment bone formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and bone morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) and iii) both ELP and PEA/FN/BMP-2 coatings applied concurrently. The scaffold material was robust and showed biodegradability. The coatings demonstrated a significant (p < 0.05) osteogenic response in vitro in alkaline phosphatase gene upregulation and alkaline phosphatase production. The PCL-T"],"journal":["Scientific reports"],"pubmed_title":["Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo."],"pmcid":["PMC11519456"],"funding_grant_id":["NIHR133314","BB/P017711/1","MINGRAFT","MR/R015651/1"],"pubmed_authors":["Salmeron-Sanchez M","Hasan A","Stevens MM","Jayawarna V","Kanczler JM","Mata A","Wojciechowski JP","Ovrebo O","Marshall KM","Yang T","Oreffo ROC","Zhou K","Echalier C"],"additional_accession":[]},"is_claimable":false,"name":"Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo.","description":"Bone tissue engineering aims to harness materials to develop functional bone tissue to heal 'critical-sized' bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed to augment bone formation. Following optimisation of the coatings, three bioactive coatings were examined, i) elastin-like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA), fibronectin (FN) and bone morphogenetic protein-2 (BMP-2) applied sequentially (PEA/FN/BMP-2) and iii) both ELP and PEA/FN/BMP-2 coatings applied concurrently. The scaffold material was robust and showed biodegradability. The coatings demonstrated a significant (p < 0.05) osteogenic response in vitro in alkaline phosphatase gene upregulation and alkaline phosphatase production. The PCL-T","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T14:47:31.382Z","creation":"2025-04-04T01:02:33.356Z"},"accession":"S-EPMC11519456","cross_references":{"pubmed":["39468149"],"doi":["10.1038/s41598-024-75198-3"]}}