{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schall TA"],"funding":["U.S. Department of Health &amp; Human Services | NIH | National Institute on Drug Abuse (NIDA)","NIDA NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Institute on Drug Abuse","NINDS NIH HHS"],"pagination":["9285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519475"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["The nucleus accumbens (NAc) regulates reward-motivated behavior, but the temporal dynamics of NAc neurons that enable \"free-willed\" animals to obtain rewards remain elusive. Here, we recorded Ca<sup>2+</sup> activity from individual NAc neurons when mice performed self-paced lever-presses for sucrose. NAc neurons exhibited three temporally-sequenced clusters, defined by times at which they exhibited increased Ca<sup>2+</sup> activity: approximately 0, -2.5 or -5 sec relative to the lever-pressing. Dopamine D1 receptor (D1)-expressing neurons and D2-neurons formed the majority of the -5-sec versus -2.5-sec clusters, respectively, while both neuronal subtypes were represented in the 0-sec cluster. We found that pre-press activity patterns of D1- or D2-neurons could predict subsequent lever-p"],"journal":["Nature communications"],"pubmed_title":["Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking."],"pmcid":["PMC11519475"],"funding_grant_id":["DA60868","DA51010","DA46491","T32 NS007433","R01 DA046491","DA53388","DA23206","R21 DA051010","R01 DA040620","R01 DA060868","K99 DA053388","R01 DA023206","R00 DA053388","DA40620","R37 DA023206"],"pubmed_authors":["Alpaugh EE","Liu J","Dong Y","Wright WJ","Li Q","Lee BT","Nestler EJ","Zhao RJ","Wang L","Zeng B","Schall TA","Huang YH","Nieh EH","Qi X","Schluter OM","Li KL"],"additional_accession":[]},"is_claimable":false,"name":"Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.","description":"The nucleus accumbens (NAc) regulates reward-motivated behavior, but the temporal dynamics of NAc neurons that enable \"free-willed\" animals to obtain rewards remain elusive. Here, we recorded Ca<sup>2+</sup> activity from individual NAc neurons when mice performed self-paced lever-presses for sucrose. NAc neurons exhibited three temporally-sequenced clusters, defined by times at which they exhibited increased Ca<sup>2+</sup> activity: approximately 0, -2.5 or -5 sec relative to the lever-pressing. Dopamine D1 receptor (D1)-expressing neurons and D2-neurons formed the majority of the -5-sec versus -2.5-sec clusters, respectively, while both neuronal subtypes were represented in the 0-sec cluster. We found that pre-press activity patterns of D1- or D2-neurons could predict subsequent lever-p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T17:45:54.775Z","creation":"2025-04-04T03:01:33.698Z"},"accession":"S-EPMC11519475","cross_references":{"pubmed":["39468146"],"doi":["10.1038/s41467-024-53690-8"]}}