{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Hubei Provincial Natural Science Foundation Project","China Health Promotion Foundation","Hubei Key Laboratory of Molecular Imaging","Beijing Health Promotion Foundation"],"pagination":["25810"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519562"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["To explore the performance of <sup>99m</sup>Tc-diethylene triaminepentaacetic acid (DTPA) SPECT/CT texture analysis in evaluating the activity of thyroid-associated ophthalmopathy (TAO) . This retrospective study examined 115 TAO patients from a single institution as an internal cohort and 58 TAO patients from another institution as an external validation set. Patients in the internal cohort were randomly divided into training (n = 81) and internal validation sets (n = 34). Radiomics signatures were constructed with the minimal redundancy maximal relevance and least absolute shrinkage and selection operator algorithms in training set. Multivariate logistic regression analysis was used to develop a clinical model and a combined clinical-radiomics model. Diagnostic performance of models was "],"journal":["Scientific reports"],"pubmed_title":["Diagnostic precision in thyroid-associated ophthalmopathy using multi-center radiomics with &lt;sup&gt;99m&lt;/sup&gt;Tc-DTPA SPECT/CT."],"pmcid":["PMC11519562"],"funding_grant_id":["2024AFB633","2020FZYX016","BJHPA-2022-JZHXZHQNYJ-LCH-03","2020 Thyroid Research Program of Young and Middle-aged Physicians"],"pubmed_authors":["Liu Y","Hu F","Xia X","Hu S","Zhao M","Ma L","Cao W","Hu M","Chen H","Li M","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic precision in thyroid-associated ophthalmopathy using multi-center radiomics with &lt;sup&gt;99m&lt;/sup&gt;Tc-DTPA SPECT/CT.","description":"To explore the performance of <sup>99m</sup>Tc-diethylene triaminepentaacetic acid (DTPA) SPECT/CT texture analysis in evaluating the activity of thyroid-associated ophthalmopathy (TAO) . This retrospective study examined 115 TAO patients from a single institution as an internal cohort and 58 TAO patients from another institution as an external validation set. Patients in the internal cohort were randomly divided into training (n = 81) and internal validation sets (n = 34). Radiomics signatures were constructed with the minimal redundancy maximal relevance and least absolute shrinkage and selection operator algorithms in training set. Multivariate logistic regression analysis was used to develop a clinical model and a combined clinical-radiomics model. Diagnostic performance of models was ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T03:01:02.063Z","creation":"2025-04-04T03:01:02.063Z"},"accession":"S-EPMC11519562","cross_references":{"pubmed":["39468140"],"doi":["10.1038/s41598-024-76018-4"]}}