{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Walkenhorst M"],"funding":["Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)","Deutsche Forschungsgemeinschaft (German Research Foundation)"],"pagination":["9287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1). Neuroinflammation in multiple sclerosis (MS) is likely initiated by autoreactive T cells and perpetuated by infiltration of additional immune cells, but the precise role of MAIT cells in MS pathogenesis remains unknown. Here, we use experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and find an accumulation of MAIT cells in the inflamed central nervous system (CNS) enriched for MAIT17 (RORγt<sup>+</sup>) and MAIT1/17 (T-bet<sup>+</sup>RORγt<sup>+</sup>) subsets with inflammatory and protective features. Results from transcriptome prof"],"journal":["Nature communications"],"pubmed_title":["Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis."],"pmcid":["PMC11519641"],"funding_grant_id":["01GI1605C","Grant No. 470154978; WI 5322/2-1"],"pubmed_authors":["Sonner JK","Winschel I","Unger L","Lantz O","Woo MS","Raich L","Winkler I","Walkenhorst M","Meurs N","Vieira V","Willing A","Bauer S","Salinas G","Engler JB","Friese MA"],"additional_accession":[]},"is_claimable":false,"name":"Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis.","description":"Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1). Neuroinflammation in multiple sclerosis (MS) is likely initiated by autoreactive T cells and perpetuated by infiltration of additional immune cells, but the precise role of MAIT cells in MS pathogenesis remains unknown. Here, we use experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and find an accumulation of MAIT cells in the inflamed central nervous system (CNS) enriched for MAIT17 (RORγt<sup>+</sup>) and MAIT1/17 (T-bet<sup>+</sup>RORγt<sup>+</sup>) subsets with inflammatory and protective features. Results from transcriptome prof","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-05T09:12:14.989Z","creation":"2025-04-05T09:12:14.989Z"},"accession":"S-EPMC11519641","cross_references":{"pubmed":["39468055"],"doi":["10.1038/s41467-024-53657-9"]}}