{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(3)"],"submitter":["Imbery JF"],"pubmed_abstract":["Chronic lymphocytic leukemia (CLL) growth is dependent on both B cell receptor (BCR) signaling and signals from microenvironmental T helper (Th) cells. We previously described a mechanism where Th cells enhance BCR signaling and proliferation through CD45 phosphatase activity regulation via galectin-1 and CD43. The CLL negative prognostic indicator CD38 is linked to BCR signaling and proliferation, with its expression induced by Th cells. Here, we explore a link between CD38 and CD45 phosphatase activity regulation using patient-derived material in a Th-CLL cell co-culture model. Results demonstrate CD43 and galectin-1 are co-expressed with CD38, defining proliferative CLL cells with augmented CD45 activity. CD38 enzymatic and receptor inhibition regulated CD43 and galectin-1 expression, C"],"journal":["Molecular therapy. Oncology"],"pagination":["200841"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519781"],"repository":["biostudies-literature"],"pubmed_title":["CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity."],"pmcid":["PMC11519781"],"pubmed_authors":["Bottini N","Imbery JF","Stanford SM","Wiik C","Dobbing MK","Heinzelbecker J","Szodoray P","Jebsen JK","Munthe LA","Nakken B","Tjonnfjord GE","Tveita A"],"additional_accession":[]},"is_claimable":false,"name":"CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity.","description":"Chronic lymphocytic leukemia (CLL) growth is dependent on both B cell receptor (BCR) signaling and signals from microenvironmental T helper (Th) cells. We previously described a mechanism where Th cells enhance BCR signaling and proliferation through CD45 phosphatase activity regulation via galectin-1 and CD43. The CLL negative prognostic indicator CD38 is linked to BCR signaling and proliferation, with its expression induced by Th cells. Here, we explore a link between CD38 and CD45 phosphatase activity regulation using patient-derived material in a Th-CLL cell co-culture model. Results demonstrate CD43 and galectin-1 are co-expressed with CD38, defining proliferative CLL cells with augmented CD45 activity. CD38 enzymatic and receptor inhibition regulated CD43 and galectin-1 expression, C","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-07-16T07:19:00.278Z","creation":"2025-04-06T15:30:21.734Z"},"accession":"S-EPMC11519781","cross_references":{"pubmed":["39474602"],"doi":["10.1016/j.omton.2024.200841"]}}