{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(17)"],"submitter":["Hang L"],"pubmed_abstract":["<b>Rationale:</b> A promising dye for phototheranostics, IR-1048 is a near-infrared region II (NIR-II) cyanine dye that exhibits exceptional optical characteristics in NIR-II spectrum. Unfortunately, the biological applications of IR-1048 are challenged by its hydrophobic nature, the formation of face-to-face stacked dimeric aggregates (H-aggregates) that result in pronounced spectral blue shifts, and issues related to fluorescence quenching. <b>Method:</b> We present a novel docking strategy involving bovine serum albumin (BSA) and lactoferrin (Lf) to construct BSA@IR-1048 and Lf@IR-1048 nanoprobes. The NIR-II optical characteristics of these nanoprobes have been thoroughly investigated through both theoretical and experimental approaches. In addition, we conducted <i>in vitro</i> and <i>"],"journal":["Theranostics"],"pagination":["6671-6691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11519796"],"repository":["biostudies-literature"],"pubmed_title":["Lactoferrin docking NIR-II cyanine dye as a potentiated phototheranostic for synchronous multimodal bioimaging and tumor photo-immunotherapy."],"pmcid":["PMC11519796"],"pubmed_authors":["Li H","Diao Y","Zhang T","Li S","Jiang G","Hang L","Qu H","Wu W","Sun Y","Fang L","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Lactoferrin docking NIR-II cyanine dye as a potentiated phototheranostic for synchronous multimodal bioimaging and tumor photo-immunotherapy.","description":"<b>Rationale:</b> A promising dye for phototheranostics, IR-1048 is a near-infrared region II (NIR-II) cyanine dye that exhibits exceptional optical characteristics in NIR-II spectrum. Unfortunately, the biological applications of IR-1048 are challenged by its hydrophobic nature, the formation of face-to-face stacked dimeric aggregates (H-aggregates) that result in pronounced spectral blue shifts, and issues related to fluorescence quenching. <b>Method:</b> We present a novel docking strategy involving bovine serum albumin (BSA) and lactoferrin (Lf) to construct BSA@IR-1048 and Lf@IR-1048 nanoprobes. The NIR-II optical characteristics of these nanoprobes have been thoroughly investigated through both theoretical and experimental approaches. In addition, we conducted <i>in vitro</i> and <i>","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-05T14:59:48.76Z","creation":"2025-04-05T14:59:48.76Z"},"accession":"S-EPMC11519796","cross_references":{"pubmed":["39479444"],"doi":["10.7150/thno.102663"]}}