{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bernal J"],"funding":["Deutsches Zentrum für Neurodegenerative Erkrankungen","Deutsche Forschungsgemeinschaft","Otto-von-Guericke-Universität Magdeburg"],"pagination":["240"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11520063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis nonetheless remain scarce.<h4>Methods</h4>We applied global and regional bivariate latent growth curve modelling to determine the extent to which WMH and cortical thickness were interrelated over a four-year period. For this purpose, we leveraged longitudinal MRI data from 451 cognitively unimpaired participants (DELCODE; median age 69.71 [IQR 65.51, 75.50] years; 52.32% female). Participants underwent MRI sessions annually over a four-year period (1815 sessions in total, with roughly four MRI sessions per participant). We adjusted all models for demogr"],"journal":["Alzheimer's research & therapy"],"pubmed_title":["Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults."],"pmcid":["PMC11520063"],"funding_grant_id":["CRC 1436, projects A05, B02, B04 and C01","BN012"],"pubmed_authors":["Duzel E","Schott BH","Hetzer S","Spottke A","Rostamzadeh A","Ziegler G","Rauchmann BS","Glanz W","Perneczky R","Lusebrink F","Schreiber S","Bernal J","Hellmann-Regen J","Schneider A","Freiesleben SD","Buerger K","Janowitz D","Peters O","Priller J","Laske C","Dechent P","Spruth EJ","Ewers M","Sodenkamp S","Jessen F","Wiltfang J","Menze I","Yakupov R","Teipel S","Scheffler K","Fliessbach K","Altenstein S","Kilimann I","Esser A","Incesoy EI"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults.","description":"<h4>Background</h4>For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis nonetheless remain scarce.<h4>Methods</h4>We applied global and regional bivariate latent growth curve modelling to determine the extent to which WMH and cortical thickness were interrelated over a four-year period. For this purpose, we leveraged longitudinal MRI data from 451 cognitively unimpaired participants (DELCODE; median age 69.71 [IQR 65.51, 75.50] years; 52.32% female). Participants underwent MRI sessions annually over a four-year period (1815 sessions in total, with roughly four MRI sessions per participant). We adjusted all models for demogr","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T15:32:15.048Z","creation":"2025-04-04T01:02:16.24Z"},"accession":"S-EPMC11520063","cross_references":{"pubmed":["39465440"],"doi":["10.1186/s13195-024-01606-5"]}}