{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gomez-Mejia A"],"funding":["Swiss National Science Foundation"],"pagination":["e0043024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11520294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(10)"],"pubmed_abstract":["The human pathobiont <i>Streptococcus pyogenes</i> forms biofilms and causes infections, such as pharyngotonsillitis and necrotizing fasciitis. Bacterial biofilms are more resilient to antibiotic treatment, and new therapeutic strategies are needed to control biofilm-associated infections, such as recurrent pharyngotonsillitis. <i>Lactiplantibacillus plantarum</i> and <i>Lacticaseibacillus rhamnosus</i> are two bacterial commensals used for their probiotic properties. This study aimed to elucidate the anti-biofilm properties of <i>L. plantarum</i> and <i>L. rhamnosus</i> cell-free supernatants (LPSN and LRSN, respectively) on <i>S. pyogenes</i> biofilms grown <i>in vitro</i> in supplemented minimal medium. When planktonic or biofilm <i>S. pyogenes</i> were exposed to LPSN or LRSN<i>, S. py"],"journal":["mSphere"],"pubmed_title":["Inhibition of <i>Streptococcus pyogenes</i> biofilm by <i>Lactiplantibacillus plantarum</i> and <i>Lacticaseibacillus rhamnosus</i>."],"pmcid":["PMC11520294"],"funding_grant_id":["169962","204343","310030"],"pubmed_authors":["Mairpady Shambat S","Gomez-Mejia A","Orlietti M","Zinkernagel AS","Tarnutzer A"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of <i>Streptococcus pyogenes</i> biofilm by <i>Lactiplantibacillus plantarum</i> and <i>Lacticaseibacillus rhamnosus</i>.","description":"The human pathobiont <i>Streptococcus pyogenes</i> forms biofilms and causes infections, such as pharyngotonsillitis and necrotizing fasciitis. Bacterial biofilms are more resilient to antibiotic treatment, and new therapeutic strategies are needed to control biofilm-associated infections, such as recurrent pharyngotonsillitis. <i>Lactiplantibacillus plantarum</i> and <i>Lacticaseibacillus rhamnosus</i> are two bacterial commensals used for their probiotic properties. This study aimed to elucidate the anti-biofilm properties of <i>L. plantarum</i> and <i>L. rhamnosus</i> cell-free supernatants (LPSN and LRSN, respectively) on <i>S. pyogenes</i> biofilms grown <i>in vitro</i> in supplemented minimal medium. When planktonic or biofilm <i>S. pyogenes</i> were exposed to LPSN or LRSN<i>, S. py","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T14:50:30.511Z","creation":"2025-04-04T01:02:42.366Z"},"accession":"S-EPMC11520294","cross_references":{"pubmed":["39360839"],"doi":["10.1128/msphere.00430-24"]}}