{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gates LA"],"funding":["Crohn’s and Colitis Foundation","Crohn's and Colitis Foundation (Crohn's & Colitis Foundation)","U.S. Department of Health &amp; Human Services | NIH | National Institute of General Medical Sciences","NICHD NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)","NIAID NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Institute of Allergy and Infectious Diseases","U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","NCI NIH HHS","NIGMS NIH HHS","U.S. Department of Health &amp; Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development"],"pagination":["697-707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11520355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(4)"],"pubmed_abstract":["Post-translational modifications (PTMs) on histones are a key source of regulation on chromatin through impacting cellular processes, including gene expression<sup>1</sup>. These PTMs often arise from metabolites and are thus impacted by metabolism and environmental cues<sup>2-7</sup>. One class of metabolically regulated PTMs are histone acylations, which include histone acetylation, butyrylation, crotonylation and propionylation<sup>3,8</sup>. As these PTMs can be derived from short-chain fatty acids, which are generated by the commensal microbiota in the intestinal lumen<sup>9-11</sup>, we aimed to define how microbes impact the host intestinal chromatin landscape, mainly in female mice. Here we show that in addition to acetylation, intestinal epithelial cells from the caecum and distal"],"journal":["Nature metabolism"],"pubmed_title":["Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression."],"pmcid":["PMC11520355"],"funding_grant_id":["R01 HD106051","R01HD106051","T32 CA009140","R00 GM143550","F32GM134560","RFA 598467","K99GM143550","F32 GM134560","R01AI118891","R01 AI118891","K99 GM143550"],"pubmed_authors":["Reis BS","Djomo AM","Allis CD","Unlu G","Lund PJ","Paul MR","Leboeuf M","Gates LA","Garcia BA","Nadeem Z","Vitorino FN","Carroll TS","Birsoy K","Lopes M","Mucida D"],"additional_accession":[]},"is_claimable":false,"name":"Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression.","description":"Post-translational modifications (PTMs) on histones are a key source of regulation on chromatin through impacting cellular processes, including gene expression<sup>1</sup>. These PTMs often arise from metabolites and are thus impacted by metabolism and environmental cues<sup>2-7</sup>. One class of metabolically regulated PTMs are histone acylations, which include histone acetylation, butyrylation, crotonylation and propionylation<sup>3,8</sup>. As these PTMs can be derived from short-chain fatty acids, which are generated by the commensal microbiota in the intestinal lumen<sup>9-11</sup>, we aimed to define how microbes impact the host intestinal chromatin landscape, mainly in female mice. Here we show that in addition to acetylation, intestinal epithelial cells from the caecum and distal","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-19T18:15:25.984Z","creation":"2025-04-19T18:15:25.984Z"},"accession":"S-EPMC11520355","cross_references":{"pubmed":["38413806"],"doi":["10.1038/s42255-024-00992-2"]}}