{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sa L"],"funding":["the Xi'an Honghui Hospital grant","the Key R&amp;D Plan of Shaanxi Province","the Key R&D Plan of Shaanxi Province","the Xi'an Municipal Health Commission grant","the State Key Laboratory of Cancer Biology Project","the Xi&apos;an Honghui Hospital grant","the Xi&apos;an Municipal Health Commission grant","the National Natural Science Foundation of China"],"pagination":["522"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11520469"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Background</h4>Several tetraspanin (TSPAN) proteins have been implicated in tumorigenesis and disease progression. However, the precise function of tetraspanin 6 (TSPAN6) in glioma remains unclear.<h4>Methods</h4>Integrated raw data from the Tumor Genome Atlas (TCGA) and Gene Expression Profiling (GEO) databases were processed using R4.2.1. Bioinformatic methods were used to analyze the gene expression levels of TSPAN6 in both glioma and normal brain tissues, correlating them with clinical characteristics. Additionally, the predictive value of TSPAN6 in relation to the immune checkpoint blockade (ICB) therapy response was assessed. In vitro experiments were conducted to investigate the effects of TSPAN6 knockdown on glioma cell proliferation, migration, cell cycle regulation, and macro"],"journal":["European journal of medical research"],"pubmed_title":["Diagnostic and prognostic significance of tetraspanin 6 and its role in facilitating glioma progression."],"pmcid":["PMC11520469"],"funding_grant_id":["202001","2023-YBSF-667","2022ms06","CBSKL2022ZZ21","82073361"],"pubmed_authors":["Jiang J","Li Y","Huo Y","Zhang H","Wang T","Shan L","Zhang L","Zheng W","Sa L"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic and prognostic significance of tetraspanin 6 and its role in facilitating glioma progression.","description":"<h4>Background</h4>Several tetraspanin (TSPAN) proteins have been implicated in tumorigenesis and disease progression. However, the precise function of tetraspanin 6 (TSPAN6) in glioma remains unclear.<h4>Methods</h4>Integrated raw data from the Tumor Genome Atlas (TCGA) and Gene Expression Profiling (GEO) databases were processed using R4.2.1. Bioinformatic methods were used to analyze the gene expression levels of TSPAN6 in both glioma and normal brain tissues, correlating them with clinical characteristics. Additionally, the predictive value of TSPAN6 in relation to the immune checkpoint blockade (ICB) therapy response was assessed. In vitro experiments were conducted to investigate the effects of TSPAN6 knockdown on glioma cell proliferation, migration, cell cycle regulation, and macro","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-02T06:21:26.405Z","creation":"2025-04-04T09:58:39.675Z"},"accession":"S-EPMC11520469","cross_references":{"pubmed":["39472973"],"doi":["10.1186/s40001-024-02119-5"]}}