biostudies-literatureUnknown485(4)Karancsi ZSemmelweis University<h4>Purpose</h4>Tumour-stroma ratio (TSR) is an important prognostic and predictive factor in several tumour types. The aim of this study is to determine whether TSR evaluated in breast cancer core biopsies is representative of the whole tumour.<h4>Method</h4>Different TSR scoring methods, their reproducibility, and the association of TSR with clinicopathological characteristics were investigated in 178 breast carcinoma core biopsies and corresponding resection specimens. TSR was assessed by two trained scientists on the most representative H&E-stained digitised slides. Patients were treated primarily with surgery between 2010 and 2021 at Semmelweis University, Budapest.<h4>Results</h4>Ninety-one percent of the tumours were hormone receptor (HR)-positive (luminal-like). Interobserver agreeVirchows Archiv : an international journal of pathology703-716https://www.ebi.ac.uk/biostudies/studies/S-EPMC11522047biostudies-literatureTumour-stroma ratio (TSR) in breast cancer: comparison of scoring core biopsies versus resection specimens.PMC11522047Hagenaars SCMesker WEKarancsi ZNemeth KKulka JTokes AMfalseTumour-stroma ratio (TSR) in breast cancer: comparison of scoring core biopsies versus resection specimens.<h4>Purpose</h4>Tumour-stroma ratio (TSR) is an important prognostic and predictive factor in several tumour types. The aim of this study is to determine whether TSR evaluated in breast cancer core biopsies is representative of the whole tumour.<h4>Method</h4>Different TSR scoring methods, their reproducibility, and the association of TSR with clinicopathological characteristics were investigated in 178 breast carcinoma core biopsies and corresponding resection specimens. TSR was assessed by two trained scientists on the most representative H&E-stained digitised slides. Patients were treated primarily with surgery between 2010 and 2021 at Semmelweis University, Budapest.<h4>Results</h4>Ninety-one percent of the tumours were hormone receptor (HR)-positive (luminal-like). Interobserver agree2024-01-01T00:00:00Z2024 Oct2026-07-15T15:31:23.126Z2025-04-19T18:11:35.232ZS-EPMC115220473719832710.1007/s00428-023-03555-0