{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang HY"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["9337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11522483"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation into pro-inflammatory macrophages. Therefore, whether blocking inflammatory monocytes can mitigate disease progression is being actively evaluated. Here, we employ multiple lineage-tracing models and show that monocyte-derived macrophages (mo-mac) are the major population of immunosuppressive, liver metastasis-associated macrophages (LMAM), while the proportion of Kupffer cells (KC) as liver-resident macrophages is diminished in metastatic nodules. Paradoxically, genetic ablation of mo-macs results in only a marginal decrease in LMAMs. Using a proliferation-recording system and a KC-tracing model in a monocyte-deficient background, we find that LMAMs can be replenished either via increased lo"],"journal":["Nature communications"],"pubmed_title":["Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells."],"pmcid":["PMC11522483"],"funding_grant_id":["82173278"],"pubmed_authors":["Tian L","Zhao C","Huang HY","Ju HQ","Shi YX","Chen YZ","Yue JX","Yu K","Zheng XN"],"additional_accession":[]},"is_claimable":false,"name":"Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells.","description":"Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation into pro-inflammatory macrophages. Therefore, whether blocking inflammatory monocytes can mitigate disease progression is being actively evaluated. Here, we employ multiple lineage-tracing models and show that monocyte-derived macrophages (mo-mac) are the major population of immunosuppressive, liver metastasis-associated macrophages (LMAM), while the proportion of Kupffer cells (KC) as liver-resident macrophages is diminished in metastatic nodules. Paradoxically, genetic ablation of mo-macs results in only a marginal decrease in LMAMs. Using a proliferation-recording system and a KC-tracing model in a monocyte-deficient background, we find that LMAMs can be replenished either via increased lo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-16T03:10:11.412Z","creation":"2025-04-04T01:59:57.4Z"},"accession":"S-EPMC11522483","cross_references":{"pubmed":["39472435"],"doi":["10.1038/s41467-024-53659-7"]}}