{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen HL"],"funding":["China Medical University Hospital (CMUH)","Academia Sinica"],"pagination":["9317"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11522641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan (n = 25,345) and the United Kin"],"journal":["Nature communications"],"pubmed_title":["Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan."],"pmcid":["PMC11522641"],"funding_grant_id":["DMR-113-117","DMR-112-119","DMR-112-188","AS-HLGC-111-04"],"pubmed_authors":["Lin YT","Yeh HC","Chang DR","Wang CCN","Kuo CC","Lin CC","Cheng CF","Lee CY","Huang CF","Tin A","Chen HL","Chiang HY","Chattopadhyay A","Tsai FJ","Yu PT","Tsai HK","Ting IW","Chuang EY","Lu TP","Lin CH"],"additional_accession":[]},"is_claimable":false,"name":"Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.","description":"Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan (n = 25,345) and the United Kin","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T14:42:18.967Z","creation":"2025-04-04T22:47:51.754Z"},"accession":"S-EPMC11522641","cross_references":{"pubmed":["39472450"],"doi":["10.1038/s41467-024-53516-7"]}}