biostudies-literatureChen HLChina Medical University Hospital (CMUH)Academia Sinica9317https://www.ebi.ac.uk/biostudies/studies/S-EPMC11522641biostudies-literatureUnknown15(1)Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan (n = 25,345) and the United KinNature communicationsDiscovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.PMC11522641DMR-113-117DMR-112-119DMR-112-188AS-HLGC-111-04Lin YTYeh HCChang DRWang CCNKuo CCLin CCCheng CFLee CYHuang CFTin AChen HLChiang HYChattopadhyay ATsai FJYu PTTsai HKTing IWChuang EYLu TPLin CHfalseDiscovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan (n = 25,345) and the United Kin2024-01-01T00:00:00Z2024 Oct2026-07-15T14:42:18.967Z2025-04-04T22:47:51.754ZS-EPMC115226413947245010.1038/s41467-024-53516-7