{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuwano T"],"funding":["Japan Agency for Medical Research and Development"],"pagination":["26057"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11522698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["There have been several reports of skin manifestations in patients with coronavirus disease 2019 (COVID-19). However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA can be detected on the skin surface, including the sebum, of these patients. In this study, SARS-CoV-2 RNA was detected using real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of skin surface lipids (SSLs) collected using an oil-blotting film from the faces of hospitalized patients with COVID-19. Human transcriptome analysis was also performed using the same samples. In facial SSLs of patients with COVID-19, the RT-PCR positivity rate was 84.6% (11/13 samples) within 5 days and 30.4% (7/23 samples) by 6-10 days of symptom onset. In the transcriptome analysis, the mo"],"journal":["Scientific reports"],"pubmed_title":["Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids."],"pmcid":["PMC11522698"],"funding_grant_id":["JP21fk0108104"],"pubmed_authors":["Nagai H","Suzuki T","Tsutsumi T","Kawana-Tachikawa A","Kuwano T","Yotsuyanagi H","Iwamura M","Fukushima K","Kobayashi T","Koga M","Miyazato Y","Tobiume M","Imamura A","Kanno T","Kutsuna S","Tanaka M","Kinoshita-Iwamoto N","Inoue T","Matano T","Yoshikawa N","Ueda Y","Hirata Y","Ohmagari N","Takada N","Katano H"],"additional_accession":[]},"is_claimable":false,"name":"Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids.","description":"There have been several reports of skin manifestations in patients with coronavirus disease 2019 (COVID-19). However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA can be detected on the skin surface, including the sebum, of these patients. In this study, SARS-CoV-2 RNA was detected using real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of skin surface lipids (SSLs) collected using an oil-blotting film from the faces of hospitalized patients with COVID-19. Human transcriptome analysis was also performed using the same samples. In facial SSLs of patients with COVID-19, the RT-PCR positivity rate was 84.6% (11/13 samples) within 5 days and 30.4% (7/23 samples) by 6-10 days of symptom onset. In the transcriptome analysis, the mo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-16T00:21:58.996Z","creation":"2025-04-06T23:17:42.673Z"},"accession":"S-EPMC11522698","cross_references":{"pubmed":["39472469"],"doi":["10.1038/s41598-024-77862-0"]}}