{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bian F"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","Herman Ostrow School of Dentistry at the University of Southern California","OREF","ASBMR Fund for Research and Education Research and Collaborative Grant","NIDCR NIH HHS","Faculty Research Seed Grant","Start-up Fund","National Institute of Dental and Craniofacial Research","NIAMS NIH HHS"],"pagination":["1644-1658"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11523133"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(11)"],"pubmed_abstract":["The cartilage growth plate is essential for maintaining skeletal growth; however, the mechanisms governing postnatal growth plate homeostasis are still poorly understood. Using approaches of molecular mouse genetics and spatial transcriptomics applied to formalin-fixed, paraffin-embedded tissues, we show that ADGRG6/GPR126, a cartilage-enriched adhesion G protein-coupled receptor (GPCR), is essential for maintaining slow-cycling resting zone cells, appropriate chondrocyte proliferation and differentiation, and growth plate homeostasis in mice. Constitutive ablation of Adgrg6 in osteochondral progenitor cells with Col2a1Cre leads to a shortened resting zone, formation of cell clusters within the proliferative zone, and an elongated hypertrophic growth plate, marked by limited expression of "],"journal":["Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"],"pubmed_title":["The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling."],"pmcid":["PMC11523133"],"funding_grant_id":["R01AR072009","R01 DE012711","R00AR075899","R00 AR077090","R01DE012711","R00AR077090","R01 AR072009","L40 AR079806"],"pubmed_authors":["Liu Z","Wu CL","He J","Feng K","Hansen V","Feng HC","Ebrahimi B","Chen Y","Chai Y","Bian F","Gray RS"],"additional_accession":[]},"is_claimable":false,"name":"The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling.","description":"The cartilage growth plate is essential for maintaining skeletal growth; however, the mechanisms governing postnatal growth plate homeostasis are still poorly understood. Using approaches of molecular mouse genetics and spatial transcriptomics applied to formalin-fixed, paraffin-embedded tissues, we show that ADGRG6/GPR126, a cartilage-enriched adhesion G protein-coupled receptor (GPCR), is essential for maintaining slow-cycling resting zone cells, appropriate chondrocyte proliferation and differentiation, and growth plate homeostasis in mice. Constitutive ablation of Adgrg6 in osteochondral progenitor cells with Col2a1Cre leads to a shortened resting zone, formation of cell clusters within the proliferative zone, and an elongated hypertrophic growth plate, marked by limited expression of ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T03:01:06.61Z","creation":"2025-04-04T03:01:06.61Z"},"accession":"S-EPMC11523133","cross_references":{"pubmed":["39236220"],"doi":["10.1093/jbmr/zjae144"]}}