{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gonzalez-Gonzalez A"],"funding":["Secretaria de Investigacion y Posgrado from Instituto Politecnico Nacional","Programa de Recursos Fiscales para Investigación from Instituto Nacional de Pediatría"],"pagination":["2413018"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11523249"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(1)"],"pubmed_abstract":["In this study, n-butyl and iso-butyl quinoxaline-7-carboxylate-1,4-di-<i>N</i>-oxide derivatives were evaluated <i>in vitro</i> against <i>Giardia lamblia</i> (<i>G. lamblia</i>)<i>, Trichomonas vaginalis</i> (<i>T. vaginalis</i>), and <i>Entamoeba histolytica</i> (<i>E. histolytica</i>). The potential mechanism of action determination was approached by <i>in silico</i> analysis on <i>G. lamblia</i> and <i>T. vaginalis</i> triosephosphate isomerase (<i>Gl</i>TIM and <i>Tv</i>TIM, respectively), and on <i>E. histolytica</i> thioredoxin reductase (<i>EhTrxR</i>). Enzyme inactivation assays were performed on recombinant G<i>l</i>TIM and <i>Eh</i>TrxR. Compound T-167 showed the best giardicidal activity (IC<sub>50</sub> = 25.53 nM) and the highest inactivation efficiency against G<i>l</i>TIM w"],"journal":["Journal of enzyme inhibition and medicinal chemistry"],"pubmed_title":["Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-<i>N</i>-oxide derivatives against <i>Giardia lamblia</i>, <i>Trichomonas vaginalis</i>, and <i>Entamoeba histolytica.</i> An <i>in vitro</i> and <i>in silico</i> approach."],"pmcid":["PMC11523249"],"funding_grant_id":["SIP-20240460","SIP-20230935","2019/062"],"pubmed_authors":["Delgado-Maldonado T","Paz-Gonzalez A","Lopez-Velazquez G","Sanchez-Sanchez O","Ortiz-Perez E","Yepez-Mulia L","Rivera G","Moreno-Rodriguez A","de la Mora-de la Mora JI","Arias D","Vazquez-Jimenez LK","Chino-Rios L","Gonzalez-Gonzalez A","Pacheco-Gutierrez S"],"additional_accession":[]},"is_claimable":false,"name":"Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-<i>N</i>-oxide derivatives against <i>Giardia lamblia</i>, <i>Trichomonas vaginalis</i>, and <i>Entamoeba histolytica.</i> An <i>in vitro</i> and <i>in silico</i> approach.","description":"In this study, n-butyl and iso-butyl quinoxaline-7-carboxylate-1,4-di-<i>N</i>-oxide derivatives were evaluated <i>in vitro</i> against <i>Giardia lamblia</i> (<i>G. lamblia</i>)<i>, Trichomonas vaginalis</i> (<i>T. vaginalis</i>), and <i>Entamoeba histolytica</i> (<i>E. histolytica</i>). The potential mechanism of action determination was approached by <i>in silico</i> analysis on <i>G. lamblia</i> and <i>T. vaginalis</i> triosephosphate isomerase (<i>Gl</i>TIM and <i>Tv</i>TIM, respectively), and on <i>E. histolytica</i> thioredoxin reductase (<i>EhTrxR</i>). Enzyme inactivation assays were performed on recombinant G<i>l</i>TIM and <i>Eh</i>TrxR. Compound T-167 showed the best giardicidal activity (IC<sub>50</sub> = 25.53 nM) and the highest inactivation efficiency against G<i>l</i>TIM w","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-02T22:14:01.752Z","creation":"2025-04-06T14:25:08.995Z"},"accession":"S-EPMC11523249","cross_references":{"pubmed":["39470324"],"doi":["10.1080/14756366.2024.2413018"]}}