biostudies-literatureUnknownPiedra HFFundación para el Fomento en Asturias de la Investigación Científica Aplicada y la TecnologíaMinisterio de Ciencia, Innovación y UniversidadesUniversidad de OviedoThe first visible-light-induced protocol for the general preparation of alkenyl thiocyanates from alkenyl bromides is presented. The reaction is simple, proceeds under very mild conditions and demonstrates broad functional group tolerance. Additionally, a flow protocol was developed to enable efficient scale-up of alkenyl thiocyanate synthesis, further enhancing the practicality and value of the method. Importantly, these alkenyl thiocyanates serve as valuable building blocks for the construction of diverse families of sulfur-containing molecules through trifluoromethylations, cycloadditions, oxidations, and C-S or P-S bond forming reactions.Chemical sciencehttps://www.ebi.ac.uk/biostudies/studies/S-EPMC11523809biostudies-literatureVisible-light-driven synthesis of alkenyl thiocyanates: novel building blocks for assembly of diverse sulfur-containing molecules.PMC11523809BP21/050MCINN-23-PID2022-140635NB-I00MCINN-24-RYC2022-035485-IPAPI-23-GR-COM-04Plaza MPiedra HFfalseVisible-light-driven synthesis of alkenyl thiocyanates: novel building blocks for assembly of diverse sulfur-containing molecules.The first visible-light-induced protocol for the general preparation of alkenyl thiocyanates from alkenyl bromides is presented. The reaction is simple, proceeds under very mild conditions and demonstrates broad functional group tolerance. Additionally, a flow protocol was developed to enable efficient scale-up of alkenyl thiocyanate synthesis, further enhancing the practicality and value of the method. Importantly, these alkenyl thiocyanates serve as valuable building blocks for the construction of diverse families of sulfur-containing molecules through trifluoromethylations, cycloadditions, oxidations, and C-S or P-S bond forming reactions.2024-01-01T00:00:00Z2024 Oct2025-04-04T20:38:43.25Z2025-04-04T20:38:43.25ZS-EPMC115238093948325610.1039/d4sc06550f