{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hai HT"],"funding":["Wellcome Trust"],"pagination":["RP92344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11524586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Mortality and morbidity from tuberculous meningitis (TBM) are common, primarily due to inflammatory response to <i>Mycobacterium tuberculosis</i> infection, yet the underlying mechanisms remain poorly understood. We aimed to uncover genes and pathways associated with TBM pathogenesis and mortality, and determine the best predictors of death, utilizing whole-blood RNA sequencing from 281 Vietnamese adults with TBM, 295 pulmonary tuberculosis (PTB), and 30 healthy controls. Through weighted gene co-expression network analysis, we identified hub genes and pathways linked to TBM severity and mortality, with a consensus analysis revealing distinct patterns between HIV-positive and HIV-negative individuals. We employed multivariate elastic-net Cox regression to select candidate predictors of dea"],"journal":["eLife"],"pubmed_title":["Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis."],"pmcid":["PMC11524586"],"funding_grant_id":["10.35802/106680","10.35802/110179","10.35802/206724","206724/Z/17/Z"],"pubmed_authors":["Bang ND","Thwaites GE","Thuong Thuong NT","Van Thanh D","Phu NH","Vinh DD","Nghia HDT","Donovan J","Inouye M","Tram TTB","Van LH","Ha DTM","Nath AP","Hai HT","Thanh Hoang Nhat L","Thu NTA"],"additional_accession":[]},"is_claimable":false,"name":"Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis.","description":"Mortality and morbidity from tuberculous meningitis (TBM) are common, primarily due to inflammatory response to <i>Mycobacterium tuberculosis</i> infection, yet the underlying mechanisms remain poorly understood. We aimed to uncover genes and pathways associated with TBM pathogenesis and mortality, and determine the best predictors of death, utilizing whole-blood RNA sequencing from 281 Vietnamese adults with TBM, 295 pulmonary tuberculosis (PTB), and 30 healthy controls. Through weighted gene co-expression network analysis, we identified hub genes and pathways linked to TBM severity and mortality, with a consensus analysis revealing distinct patterns between HIV-positive and HIV-negative individuals. We employed multivariate elastic-net Cox regression to select candidate predictors of dea","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T17:37:49.772Z","creation":"2025-04-04T00:26:31.782Z"},"accession":"S-EPMC11524586","cross_references":{"pubmed":["39475467"],"doi":["10.7554/eLife.92344"]}}