biostudies-literatureZheng QNational Natural Science Foundation of ChinaNational Key Research and Development Program of China101506https://www.ebi.ac.uk/biostudies/studies/S-EPMC11525147biostudies-literatureUnknown62Several human fungal pathogens, including drug-resistant <i>Candida auris</i> and species of the <i>Candida haemulonii</i> complex, have emerged over the past two decades, posing new threats to human health. In this study, we report the isolation and identification of a novel species belonging to the genus <i>Clavispora</i>, herein named as <i>Cl</i> <i>avispora</i> <i>sputum</i>, from a clinical sputum sample of a COVID-19 patient. <i>Cl</i> <i>. sputum</i> is phylogenetically closely related to fungal pathogens <i>Clavispora lusitaniae</i> (syn. <i>Candida lusitaniae</i>) and <i>C. auris</i>. When grown on CHROMagar <i>Candida</i> Plus medium, <i>Cl. sputum</i> exhibited a similar coloration to <i>C. auris</i> strain CBS12372. <i>Cl. sputum</i> was able to develop weak filaments on CM meNew microbes and new infectionsBiological and genomic analyses of <i>Clavispora sputum</i> <i>sp. nov.</i>, a novel potential fungal pathogen closely related to <i>Clavispora lusitaniae</i> (syn. <i>Candida lusitaniae</i>) and <i>Candida auris</i>.PMC11525147320000182021YFC230040082202546319300052022YFC23030003217019382272359Bing JHu THuang GGuan SChu HZheng QCai LHan SfalseBiological and genomic analyses of <i>Clavispora sputum</i> <i>sp. nov.</i>, a novel potential fungal pathogen closely related to <i>Clavispora lusitaniae</i> (syn. <i>Candida lusitaniae</i>) and <i>Candida auris</i>.Several human fungal pathogens, including drug-resistant <i>Candida auris</i> and species of the <i>Candida haemulonii</i> complex, have emerged over the past two decades, posing new threats to human health. In this study, we report the isolation and identification of a novel species belonging to the genus <i>Clavispora</i>, herein named as <i>Cl</i> <i>avispora</i> <i>sputum</i>, from a clinical sputum sample of a COVID-19 patient. <i>Cl</i> <i>. sputum</i> is phylogenetically closely related to fungal pathogens <i>Clavispora lusitaniae</i> (syn. <i>Candida lusitaniae</i>) and <i>C. auris</i>. When grown on CHROMagar <i>Candida</i> Plus medium, <i>Cl. sputum</i> exhibited a similar coloration to <i>C. auris</i> strain CBS12372. <i>Cl. sputum</i> was able to develop weak filaments on CM me2024-01-01T00:00:00Z2024 Dec2026-06-01T09:55:39.986Z2025-04-06T09:33:08.747ZS-EPMC115251473948370610.1016/j.nmni.2024.101506