{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["51"],"submitter":["Sinn K"],"funding":["City of Vienna"],"pubmed_abstract":["<h4>Objectives</h4>Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC.<h4>Materials and methods</h4>ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (stage I-IV) and 73 controls, and correlated those values with clinicopathological parameters and survival.<h4>Results</h4>ActA plasma levels were significantly higher in therapy-naive LUSC patients compared to controls (444.1 ± 310.9 pg/mL vs 338.9 ± 145.5 pg/mL, p = 0.010). ActA levels significantly correlated with advanced stage as well as with T and N factors. High circulating ActA"],"journal":["Translational oncology"],"pagination":["102153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11525229"],"repository":["biostudies-literature"],"pubmed_title":["High circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients."],"pmcid":["PMC11525229"],"pubmed_authors":["Aigner C","Laszlo V","Hoda MA","Grusch M","Elbeialy A","Schelch K","Sinn K","Mosleh B","Dome B"],"additional_accession":[]},"is_claimable":false,"name":"High circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients.","description":"<h4>Objectives</h4>Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC.<h4>Materials and methods</h4>ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (stage I-IV) and 73 controls, and correlated those values with clinicopathological parameters and survival.<h4>Results</h4>ActA plasma levels were significantly higher in therapy-naive LUSC patients compared to controls (444.1 ± 310.9 pg/mL vs 338.9 ± 145.5 pg/mL, p = 0.010). ActA levels significantly correlated with advanced stage as well as with T and N factors. High circulating ActA","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T03:01:49.403Z","creation":"2025-04-04T03:01:49.403Z"},"accession":"S-EPMC11525229","cross_references":{"pubmed":["39405924"],"doi":["10.1016/j.tranon.2024.102153"]}}