biostudies-literatureUnknown51Sinn KCity of Vienna<h4>Objectives</h4>Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC.<h4>Materials and methods</h4>ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (stage I-IV) and 73 controls, and correlated those values with clinicopathological parameters and survival.<h4>Results</h4>ActA plasma levels were significantly higher in therapy-naive LUSC patients compared to controls (444.1 ± 310.9 pg/mL vs 338.9 ± 145.5 pg/mL, p = 0.010). ActA levels significantly correlated with advanced stage as well as with T and N factors. High circulating ActATranslational oncology102153https://www.ebi.ac.uk/biostudies/studies/S-EPMC11525229biostudies-literatureHigh circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients.PMC11525229Aigner CLaszlo VHoda MAGrusch MElbeialy ASchelch KSinn KMosleh BDome BfalseHigh circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients.<h4>Objectives</h4>Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC.<h4>Materials and methods</h4>ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (stage I-IV) and 73 controls, and correlated those values with clinicopathological parameters and survival.<h4>Results</h4>ActA plasma levels were significantly higher in therapy-naive LUSC patients compared to controls (444.1 ± 310.9 pg/mL vs 338.9 ± 145.5 pg/mL, p = 0.010). ActA levels significantly correlated with advanced stage as well as with T and N factors. High circulating ActA2024-01-01T00:00:00Z2024 Oct2025-04-04T03:01:49.403Z2025-04-04T03:01:49.403ZS-EPMC115252293940592410.1016/j.tranon.2024.102153