{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tarale P"],"funding":["NIAAA NIH HHS","NIAAA"],"pagination":["279"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11526652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>Microglia, a type of resident immune cells within the central nervous system, have been implicated in ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. We determined if microglial extracellular vesicles (exosomes) are involved in the ethanol-induced neuronal death of the β-endorphin neuron via secreting elevated levels of the chemokine monocyte chemoattractant protein 1 (MCP1), a key regulator of neuroinflammation.<h4>Methods</h4>We employed an in vitro model, consisting of primary culture of hypothalamic microglia prepared from postnatal day 2 (PND2) rat hypothalami and treated with or without 50 mM ethanol for 24 h, "],"journal":["Journal of neuroinflammation"],"pubmed_title":["Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus."],"pmcid":["PMC11526652"],"funding_grant_id":["R01AA028767","R01 AA028767"],"pubmed_authors":["Tarale P","Chaudhary S","Sarkar DK","Mukherjee S"],"additional_accession":[]},"is_claimable":false,"name":"Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus.","description":"<h4>Background</h4>Microglia, a type of resident immune cells within the central nervous system, have been implicated in ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. We determined if microglial extracellular vesicles (exosomes) are involved in the ethanol-induced neuronal death of the β-endorphin neuron via secreting elevated levels of the chemokine monocyte chemoattractant protein 1 (MCP1), a key regulator of neuroinflammation.<h4>Methods</h4>We employed an in vitro model, consisting of primary culture of hypothalamic microglia prepared from postnatal day 2 (PND2) rat hypothalami and treated with or without 50 mM ethanol for 24 h, ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-05T09:12:28.228Z","creation":"2025-04-05T09:12:28.228Z"},"accession":"S-EPMC11526652","cross_references":{"pubmed":["39478585"],"doi":["10.1186/s12974-024-03274-6"]}}