{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Balbona JV"],"funding":["NIDA NIH HHS"],"pubmed_abstract":["Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, and opioid use and use disorders with indices of aging across the lifespan. There was evidence of tobacco and alcohol use and use disorders causally impacting physical, cognitive, and biological aging, with the effects of alcohol being more dependent on quantity of consumption; evidence of reverse causality was scant."],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.10.14.24315472"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527072"],"repository":["biostudies-literature"],"pubmed_title":["Examining the causal genetic effects of substance use on aging."],"pmcid":["PMC11527072"],"funding_grant_id":["R01 DA054869","K01 DA051759","T32 DA007261"],"pubmed_authors":["Bogdan R","Balbona JV","Gorelik AJ","Nelson EC","Jeffries P","Johnson EC","Agrawal A"],"additional_accession":[]},"is_claimable":false,"name":"Examining the causal genetic effects of substance use on aging.","description":"Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, and opioid use and use disorders with indices of aging across the lifespan. There was evidence of tobacco and alcohol use and use disorders causally impacting physical, cognitive, and biological aging, with the effects of alcohol being more dependent on quantity of consumption; evidence of reverse causality was scant.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T14:57:03.087Z","creation":"2025-04-04T14:57:03.087Z"},"accession":"S-EPMC11527072","cross_references":{"pubmed":["39484246"],"doi":["10.1101/2024.10.14.24315472"]}}