{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ba A"],"funding":["NIAID NIH HHS","FIC NIH HHS"],"pubmed_abstract":["The <i>Plasmodium falciparum</i> cysteine-rich protective antigen (PfCyRPA) is a promising target as a next-generation blood-stage malaria vaccine and together with PCRCR complex members, the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5-interacting protein (PfRipr), are currently being evaluated in clinical trials. PfCyRPA is essential for merozoite invasion and appears to be highly conserved within the <i>P. falciparum</i> parasite populations. Here, we used a targeted deep amplicon next-generation sequencing approach to assess the breadth of PfCyRPA genetic diversity in 95 <i>P. falciparum</i> clinical isolates from Kédougou, an area with a high seasonal malaria transmission in Senegal. Our data show the dominant prevalence of PfCyRPA wild type reference allele, whi"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.10.13.24305808"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527082"],"repository":["biostudies-literature"],"pubmed_title":["Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal."],"pmcid":["PMC11527082"],"funding_grant_id":["R01 AI168238","K01 TW010496"],"pubmed_authors":["Sheng Z","Guo Y","Moore AJ","Patel SD","Li R","Shapiro L","Pouye MN","Mbengue A","Diallo F","Sene SD","Laqqa S","Ndiaye JLA","Mangou K","Cisse A","Guerra N","Thiam LG","Sadio BD","Bei AK","Ba A"],"additional_accession":[]},"is_claimable":false,"name":"Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal.","description":"The <i>Plasmodium falciparum</i> cysteine-rich protective antigen (PfCyRPA) is a promising target as a next-generation blood-stage malaria vaccine and together with PCRCR complex members, the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5-interacting protein (PfRipr), are currently being evaluated in clinical trials. PfCyRPA is essential for merozoite invasion and appears to be highly conserved within the <i>P. falciparum</i> parasite populations. Here, we used a targeted deep amplicon next-generation sequencing approach to assess the breadth of PfCyRPA genetic diversity in 95 <i>P. falciparum</i> clinical isolates from Kédougou, an area with a high seasonal malaria transmission in Senegal. Our data show the dominant prevalence of PfCyRPA wild type reference allele, whi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-02T03:15:32.045Z","creation":"2025-04-06T10:11:39.417Z"},"accession":"S-EPMC11527082","cross_references":{"pubmed":["39484257"],"doi":["10.1101/2024.10.13.24305808"]}}