{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Valle LF"],"funding":["NCI NIH HHS","CSRD VA"],"pubmed_abstract":["<h4>Purpose</h4>National guidelines recommend next generation sequencing (NGS) of tumors in patients diagnosed with metastatic prostate cancer (mPCa) to identify potential actionable alterations. We sought to describe the spectrum and frequency of alterations in PCa-related genes and pathways, as well as associations with self-identified race/ethnicity, and overall survival in US Veterans.<h4>Patients and methods</h4>This retrospective cohort study included Non-Hispanic Black (NHB) and Non-Hispanic white (NHW) Veterans with mPCa who obtained NGS through the Veterans Affairs National Precision Oncology Program. 45 genes in seven canonical or targetable mPCa pathways were evaluated in addition to TMB and MSI status. Multivariable logistic regression evaluated associations between race/ethnic"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.24.620071"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527339"],"repository":["biostudies-literature"],"pubmed_title":["Oncogenic Alterations, Race, and Survival in US Veterans with Metastatic Prostate Cancer Undergoing Somatic Tumor Next Generation Sequencing."],"pmcid":["PMC11527339"],"funding_grant_id":["I01 CX002622","K08 CA215312","I01 CX002709","R01 CA271750","P50 CA092131"],"pubmed_authors":["Desai H","Li J","Garraway IP","Maxwell KN","Rose BS","Ojo M","Valle LF","Rebbeck T","Yamoah K","Nickols NG","Kelley MJ","Haroldsen C","Rettig MB","Chatwal M","Hausler R"],"additional_accession":[]},"is_claimable":false,"name":"Oncogenic Alterations, Race, and Survival in US Veterans with Metastatic Prostate Cancer Undergoing Somatic Tumor Next Generation Sequencing.","description":"<h4>Purpose</h4>National guidelines recommend next generation sequencing (NGS) of tumors in patients diagnosed with metastatic prostate cancer (mPCa) to identify potential actionable alterations. We sought to describe the spectrum and frequency of alterations in PCa-related genes and pathways, as well as associations with self-identified race/ethnicity, and overall survival in US Veterans.<h4>Patients and methods</h4>This retrospective cohort study included Non-Hispanic Black (NHB) and Non-Hispanic white (NHW) Veterans with mPCa who obtained NGS through the Veterans Affairs National Precision Oncology Program. 45 genes in seven canonical or targetable mPCa pathways were evaluated in addition to TMB and MSI status. Multivariable logistic regression evaluated associations between race/ethnic","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T03:06:24.594Z","creation":"2025-04-04T03:06:24.594Z"},"accession":"S-EPMC11527339","cross_references":{"pubmed":["39484518"],"doi":["10.1101/2024.10.24.620071"]}}