{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li T"],"funding":["Ministry of Science and Technology of China","Chinese Academy of Sciences","National Science and Technology Council Taiwan","Ministry of Education (MOE) in Taiwan","National Science Foundation of China"],"pagination":["RP87258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527428"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Traumatic brain injury (TBI) caused by external mechanical forces is a major health burden worldwide, but the underlying mechanism in glia remains largely unclear. We report herein that <i>Drosophila</i> adults exhibit a defective blood-brain barrier, elevated innate immune responses, and astrocyte swelling upon consecutive strikes with a high-impact trauma device. RNA sequencing (RNA-seq) analysis of these astrocytes revealed upregulated expression of genes encoding PDGF and VEGF receptor-related (Pvr, a receptor tyrosine kinase), adaptor protein complex 1 (AP-1<i>,</i> a transcription factor complex of the c-Jun N-terminal kinase pathway) composed of Jun-related antigen (Jra) and kayak (kay), and matrix metalloproteinase 1 (Mmp1) following TBI. Interestingly, Pvr is both required and suf"],"journal":["eLife"],"pubmed_title":["A Pvr-AP-1-Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury."],"pmcid":["PMC11527428"],"funding_grant_id":["31921002","32170962","2021ZD0203900","113-2628-B-A49-007","2019YFA0707100","31861143031","Higher Education Sprout Project","31830036","Strategic Priority Research Program B XDBS1020100"],"pubmed_authors":["Li T","Ho MS","Shi W","Zhang YQ"],"additional_accession":[]},"is_claimable":false,"name":"A Pvr-AP-1-Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury.","description":"Traumatic brain injury (TBI) caused by external mechanical forces is a major health burden worldwide, but the underlying mechanism in glia remains largely unclear. We report herein that <i>Drosophila</i> adults exhibit a defective blood-brain barrier, elevated innate immune responses, and astrocyte swelling upon consecutive strikes with a high-impact trauma device. RNA sequencing (RNA-seq) analysis of these astrocytes revealed upregulated expression of genes encoding PDGF and VEGF receptor-related (Pvr, a receptor tyrosine kinase), adaptor protein complex 1 (AP-1<i>,</i> a transcription factor complex of the c-Jun N-terminal kinase pathway) composed of Jun-related antigen (Jra) and kayak (kay), and matrix metalloproteinase 1 (Mmp1) following TBI. Interestingly, Pvr is both required and suf","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-05T09:12:34.313Z","creation":"2025-04-05T09:12:34.313Z"},"accession":"S-EPMC11527428","cross_references":{"pubmed":["39480704"],"doi":["10.7554/eLife.87258"]}}