{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Michels EHA"],"funding":["ZonMw"],"pagination":["1470383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["<h4>Introduction</h4>Neutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil function in CAP relies on animal studies, leaving a gap in patient-centered investigations.<h4>Methods</h4>We used mass spectrometry to characterize the neutrophil proteome of moderately ill CAP patients at general ward admission and related the proteome to controls and clinical outcomes.<h4>Results</h4>We prospectively included 57 CAP patients and 26 controls and quantified 3482 proteins in neutrophil lysates and 386 proteins in concurrently collected plasma. The extensively studied granule-related proteins in animal models did not drive the neutrophil proteome changes associated with human CAP. Proteome altera"],"journal":["Frontiers in immunology"],"pubmed_title":["Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome."],"pmcid":["PMC11527607"],"funding_grant_id":["10430142110001"],"pubmed_authors":["de Vos AF","Hoogendijk AJ","Wiersinga WJ","van der Poll T","Michels EHA","Chouchane O","Douma RA","Faber DR","de Brabander J","Smit ER","van den Biggelaar M"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome.","description":"<h4>Introduction</h4>Neutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil function in CAP relies on animal studies, leaving a gap in patient-centered investigations.<h4>Methods</h4>We used mass spectrometry to characterize the neutrophil proteome of moderately ill CAP patients at general ward admission and related the proteome to controls and clinical outcomes.<h4>Results</h4>We prospectively included 57 CAP patients and 26 controls and quantified 3482 proteins in neutrophil lysates and 386 proteins in concurrently collected plasma. The extensively studied granule-related proteins in animal models did not drive the neutrophil proteome changes associated with human CAP. Proteome altera","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-16T09:28:34.815Z","creation":"2025-04-21T21:41:19.727Z"},"accession":"S-EPMC11527607","cross_references":{"pubmed":["39493755"],"doi":["10.3389/fimmu.2024.1470383"]}}