{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Korczak L"],"pubmed_abstract":["<i>Enterobacterales</i> (especially carbapenem-resistant) are considered an urgent threat to public health. The available antibiotic therapy is limited due to the increase of multidrug-resistant (MDR) strains. Tigecycline, a minocycline derivative, has emerged as a potential key agent in the treatment of MDR isolates. The aim of the study was to evaluate the synergistic effect of tigecycline in combination with nine antimicrobial agents-ceftazidime/avibactam, colistin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem/vaborbactam, polymyxin B, and rifampicin. Eighty clinical <i>Enterobacter cloacae</i> strains were obtained from patients of two University Hospitals in Bialystok, Poland. The E-test method was used to determine synergistic interactions. Among all combinations, synergy"],"journal":["Frontiers in microbiology"],"pagination":["1490032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527652"],"repository":["biostudies-literature"],"pubmed_title":["<i>In vitro</i> evaluation of tigecycline synergy testing with nine antimicrobial agents against <i>Enterobacter cloacae</i> clinical strains."],"pmcid":["PMC11527652"],"pubmed_authors":["Korczak L","Sacha P","Majewski P","Iwaniuk D","Tryniszewska E","Rombel K","Modzelewski M"],"additional_accession":[]},"is_claimable":false,"name":"<i>In vitro</i> evaluation of tigecycline synergy testing with nine antimicrobial agents against <i>Enterobacter cloacae</i> clinical strains.","description":"<i>Enterobacterales</i> (especially carbapenem-resistant) are considered an urgent threat to public health. The available antibiotic therapy is limited due to the increase of multidrug-resistant (MDR) strains. Tigecycline, a minocycline derivative, has emerged as a potential key agent in the treatment of MDR isolates. The aim of the study was to evaluate the synergistic effect of tigecycline in combination with nine antimicrobial agents-ceftazidime/avibactam, colistin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem/vaborbactam, polymyxin B, and rifampicin. Eighty clinical <i>Enterobacter cloacae</i> strains were obtained from patients of two University Hospitals in Bialystok, Poland. The E-test method was used to determine synergistic interactions. Among all combinations, synergy","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-09T11:22:43.695Z","creation":"2025-04-04T13:19:35.013Z"},"accession":"S-EPMC11527652","cross_references":{"pubmed":["39493842"],"doi":["10.3389/fmicb.2024.1490032"]}}