biostudies-literatureUnknown15Korczak L<i>Enterobacterales</i> (especially carbapenem-resistant) are considered an urgent threat to public health. The available antibiotic therapy is limited due to the increase of multidrug-resistant (MDR) strains. Tigecycline, a minocycline derivative, has emerged as a potential key agent in the treatment of MDR isolates. The aim of the study was to evaluate the synergistic effect of tigecycline in combination with nine antimicrobial agents-ceftazidime/avibactam, colistin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem/vaborbactam, polymyxin B, and rifampicin. Eighty clinical <i>Enterobacter cloacae</i> strains were obtained from patients of two University Hospitals in Bialystok, Poland. The E-test method was used to determine synergistic interactions. Among all combinations, synergyFrontiers in microbiology1490032https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527652biostudies-literature<i>In vitro</i> evaluation of tigecycline synergy testing with nine antimicrobial agents against <i>Enterobacter cloacae</i> clinical strains.PMC11527652Korczak LSacha PMajewski PIwaniuk DTryniszewska ERombel KModzelewski Mfalse<i>In vitro</i> evaluation of tigecycline synergy testing with nine antimicrobial agents against <i>Enterobacter cloacae</i> clinical strains.<i>Enterobacterales</i> (especially carbapenem-resistant) are considered an urgent threat to public health. The available antibiotic therapy is limited due to the increase of multidrug-resistant (MDR) strains. Tigecycline, a minocycline derivative, has emerged as a potential key agent in the treatment of MDR isolates. The aim of the study was to evaluate the synergistic effect of tigecycline in combination with nine antimicrobial agents-ceftazidime/avibactam, colistin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem/vaborbactam, polymyxin B, and rifampicin. Eighty clinical <i>Enterobacter cloacae</i> strains were obtained from patients of two University Hospitals in Bialystok, Poland. The E-test method was used to determine synergistic interactions. Among all combinations, synergy2024-01-01T00:00:00Z20242026-07-09T11:22:43.695Z2025-04-04T13:19:35.013ZS-EPMC115276523949384210.3389/fmicb.2024.1490032