biostudies-literatureSaunders MNNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSNational Institutes of HealthNIH HHSNIGMS NIH HHSe2400237https://www.ebi.ac.uk/biostudies/studies/S-EPMC11527797biostudies-literatureUnknown14(5)Food allergy is a prevalent, potentially deadly disease caused by inadvertent sensitization to benign food antigens. Pathogenic Th2 cells are a major driver for disease, and allergen-specific immunotherapies (AIT) aim to increase the allergen threshold required to elicit severe allergic symptoms. However, the majority of AIT approaches require lengthy treatments and convey transient disease suppression, likely due to insufficient targeting of pathogenic Th2 responses. Here, the ability of allergen-encapsulating nanoparticles to directly suppress pathogenic Th2 responses and reactivity is investigated in a mouse model of food allergy. NPs associate with pro-tolerogenic antigen presenting cells, provoking accumulation of antigen-specific, functionally suppressive regulatory T cells in the smAdvanced healthcare materialsAllergen-Encapsulating Nanoparticles Reprogram Pathogenic Allergen-Specific Th2 Cells to Suppress Food Allergy.PMC11527797R01 AI155678R01 AI148076T32GM007863R01AI155678T32 GM007863Quiros MChiang MYLanders JJPodojil JRMiller SDBealer EJCrumley KHocevar SEO'Konek JJParkos CARoss BCUrie RRWilliams LABenson OENusrat ASaunders MNRad LMJanczak KWShea LDAngadi ARGriffin KVfalseAllergen-Encapsulating Nanoparticles Reprogram Pathogenic Allergen-Specific Th2 Cells to Suppress Food Allergy.Food allergy is a prevalent, potentially deadly disease caused by inadvertent sensitization to benign food antigens. Pathogenic Th2 cells are a major driver for disease, and allergen-specific immunotherapies (AIT) aim to increase the allergen threshold required to elicit severe allergic symptoms. However, the majority of AIT approaches require lengthy treatments and convey transient disease suppression, likely due to insufficient targeting of pathogenic Th2 responses. Here, the ability of allergen-encapsulating nanoparticles to directly suppress pathogenic Th2 responses and reactivity is investigated in a mouse model of food allergy. NPs associate with pro-tolerogenic antigen presenting cells, provoking accumulation of antigen-specific, functionally suppressive regulatory T cells in the sm2025-01-01T00:00:00Z2025 Feb2026-06-06T23:31:14.592Z2025-04-06T13:59:47.827ZS-EPMC115277973869181910.1002/adhm.202400237