{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sherman JD"],"funding":["IDCRC Early Career Investigator Pilot Award","Infectious Diseases Clinical Research","NIAID NIH HHS","London International Coordinating Centre","Complex Carbohydrate Research Center","Defense Health Program","governments of Denmark","NIAID","Department of Defense","Seoul National University Hospital","NIGMS NIH HHS"],"pagination":["ofae626"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11528514"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["Background
Severe coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) Fc afucosylation, which induces proinflammatory cytokine secretion from innate immune cells. This study aimed to define spike IgG Fc glycosylation following SARS-CoV-2 infection in adults and children and following SARS-CoV-2 vaccination in adults and the relationships between glycan modifications and cytokines/chemokines.Methods
We analyzed longitudinal (n = 146) and cross-sectional (n = 49) serum/plasma samples from adult and pediatric COVID-19 patients, MIS-C patients, a"],"journal":["Open forum infectious diseases"],"pubmed_title":["Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children."],"pmcid":["PMC11528514"],"funding_grant_id":["UM1AI148689","75N91020F00010","UM1AI148576","R24 GM137782","R24GM137782","HHSN261200800001E","MRC_UU_12023/23","UM1AI148575","UM1AI148685","UM1AI148684","75N91019F00130","UM1AI148452","UM1AI148573","UM1 AI148689","UM1AI148450","75N910D00024"],"pubmed_authors":["Sherman JD","Panjwani A","Wang D","Huerta C","Rostad CA","Karmali V","Collins MH","Rouphael N","Simon TW","Ciric CR","Anderson EJ","Scherer EM","Azadi P","Johnson B","Bechnak S","Kumar B"],"additional_accession":[]},"is_claimable":false,"name":"Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children.","description":"Background
Severe coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) Fc afucosylation, which induces proinflammatory cytokine secretion from innate immune cells. This study aimed to define spike IgG Fc glycosylation following SARS-CoV-2 infection in adults and children and following SARS-CoV-2 vaccination in adults and the relationships between glycan modifications and cytokines/chemokines.Methods
We analyzed longitudinal (n = 146) and cross-sectional (n = 49) serum/plasma samples from adult and pediatric COVID-19 patients, MIS-C patients, a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T20:38:49.011Z","creation":"2025-04-04T20:38:49.011Z"},"accession":"S-EPMC11528514","cross_references":{"pubmed":["39494457"],"doi":["10.1093/ofid/ofae626"]}}