{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["Fudan’s Undergraduate Research Opportunities Program","Shanghai Stomatological Hospital Science and Technology Innovation Talent Training Program Talent Project","Fudan University Shanghai Medical College Undergraduate Innovation Program “Qingfeng” Scholar Program","Nature Science Foundation of Shanghai","Fudan's Undergraduate Research Opportunities Program","Fudan University Shanghai Medical College Undergraduate Innovation Program \"Qingfeng\" Scholar Program"],"pagination":["1336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Background
Periodontitis is a chronic inflammatory disease characterized by the destruction of the components of the periodontium. It significantly impacts oral health and has been linked to systemic conditions like cardiovascular disease and diabetes. The critical role of neutrophils in the occurrence and development of chronic periodontitis has been paid increasing attention. The study aimed to explore the protective effects of D-mannose on chronic periodontitis and determine whether its underlying mechanisms is related to neutrophils.Methods
To explore the protective effects of D-mannose on chronic periodontitis, the eight-week-old Sprague Dawley rat model of lipopolysaccharide (LPS)-induced periodontitis was established, followed by D-mannose treatment by oral gavage. T"],"journal":["BMC oral health"],"pubmed_title":["D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils."],"pmcid":["PMC11529006"],"funding_grant_id":["SSH-2022-KJCX-B05","QF2319","20ZR1443100,21140904500","22676"],"pubmed_authors":["Li X","Lv L","Nan S","Chen X","Zhu Q","Qi S","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils.","description":"Background
Periodontitis is a chronic inflammatory disease characterized by the destruction of the components of the periodontium. It significantly impacts oral health and has been linked to systemic conditions like cardiovascular disease and diabetes. The critical role of neutrophils in the occurrence and development of chronic periodontitis has been paid increasing attention. The study aimed to explore the protective effects of D-mannose on chronic periodontitis and determine whether its underlying mechanisms is related to neutrophils.Methods
To explore the protective effects of D-mannose on chronic periodontitis, the eight-week-old Sprague Dawley rat model of lipopolysaccharide (LPS)-induced periodontitis was established, followed by D-mannose treatment by oral gavage. T","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-18T22:39:47.729Z","creation":"2025-04-07T10:23:11.135Z"},"accession":"S-EPMC11529006","cross_references":{"pubmed":["39487474"],"doi":["10.1186/s12903-024-05080-1"]}}