{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan Yi Shean L"],"funding":["Equine Grass Sickness Fund"],"pagination":["864-869"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529066"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(6)"],"pubmed_abstract":["Lipofuscin is a complex mixture of highly oxidized, cross-linked macromolecules that accumulates in neurons with age and some neurodegenerative diseases. Equine dysautonomia (ED) is a polyneuropathy that mainly affects autonomic and enteric nervous systems, resulting in alimentary tract dysfunction. Our main aim was to determine whether neuronal lipofuscin increased with increasing duration of ED. We investigated the prevalence of lipofuscin in cranial cervical ganglia of horses with acute (AED), subacute (SED), and chronic ED (CED), young controls (of similar age to ED cases), and aged controls (<i>n</i> = 8 per group). We used Schmorl stain for histologic detection of lipofuscin and assessed its accumulation in neurons using image analysis software. The percentage of neurons positive for"],"journal":["Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc"],"pubmed_title":["Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia."],"pmcid":["PMC11529066"],"funding_grant_id":["John Gilmour Summer Research Scholarship"],"pubmed_authors":["Maxwell S","Milne EM","Shaw DJ","Del-Pozo J","Tan Yi Shean L"],"additional_accession":[]},"is_claimable":false,"name":"Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia.","description":"Lipofuscin is a complex mixture of highly oxidized, cross-linked macromolecules that accumulates in neurons with age and some neurodegenerative diseases. Equine dysautonomia (ED) is a polyneuropathy that mainly affects autonomic and enteric nervous systems, resulting in alimentary tract dysfunction. Our main aim was to determine whether neuronal lipofuscin increased with increasing duration of ED. We investigated the prevalence of lipofuscin in cranial cervical ganglia of horses with acute (AED), subacute (SED), and chronic ED (CED), young controls (of similar age to ED cases), and aged controls (<i>n</i> = 8 per group). We used Schmorl stain for histologic detection of lipofuscin and assessed its accumulation in neurons using image analysis software. The percentage of neurons positive for","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-03-31T11:58:57.884Z","creation":"2025-09-01T03:08:26.518Z"},"accession":"S-EPMC11529066","cross_references":{"pubmed":["39113499"],"doi":["10.1177/10406387241265715"]}}