{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(4)"],"submitter":["Xu J"],"funding":["no funding"],"pubmed_abstract":["Angiotensin-converting enzyme 2 (ACE2) is identified as the functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the ongoing global coronavirus disease-2019 (COVID-19) pandemic. This study aimed to elucidate potential therapeutic avenues by scrutinizing approved drugs through the identification of the genetic signature associated with SARS-CoV-2 infection in individuals with asthma. This exploration was conducted through an integrated analysis, encompassing interaction networks between the ACE2 receptor and common host (co-host) factors implicated in COVID-19/asthma comorbidity. The comprehensive analysis involved the identification of common differentially expressed genes (cDEGs) and hub-cDEGs, functional annotations, interaction net"],"journal":["Cell cycle (Georgetown, Tex.)"],"pagination":["405-434"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529202"],"repository":["biostudies-literature"],"pubmed_title":["Discovery of common molecular signatures and drug repurposing for COVID-19/Asthma comorbidity: ACE2 and multi-partite networks."],"pmcid":["PMC11529202"],"pubmed_authors":["Abbas AH","Abdulsalam Khaleel R","Bahrami A","Fahmi Fawy K","Arias Gonzales JL","Zaidan HK","Faisal Mutee A","Xu J","Gehlot A","Ruiz-Balvin MC","Amin AH","Akhavan-Sigari R","Imannezhad S"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of common molecular signatures and drug repurposing for COVID-19/Asthma comorbidity: ACE2 and multi-partite networks.","description":"Angiotensin-converting enzyme 2 (ACE2) is identified as the functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the ongoing global coronavirus disease-2019 (COVID-19) pandemic. This study aimed to elucidate potential therapeutic avenues by scrutinizing approved drugs through the identification of the genetic signature associated with SARS-CoV-2 infection in individuals with asthma. This exploration was conducted through an integrated analysis, encompassing interaction networks between the ACE2 receptor and common host (co-host) factors implicated in COVID-19/asthma comorbidity. The comprehensive analysis involved the identification of common differentially expressed genes (cDEGs) and hub-cDEGs, functional annotations, interaction net","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-02T06:41:43.705Z","creation":"2026-05-25T03:07:50.816Z"},"accession":"S-EPMC11529202","cross_references":{"pubmed":["38640424"],"doi":["10.1080/15384101.2024.2340859"]}}