biostudies-literatureXie ZLingang LaboratoryNatural Science Foundation of China for Innovation Research GroupNational Natural Science Foundation of ChinaShandong Laboratory Program989https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529322biostudies-literatureUnknown22(1)<h4>Background</h4>Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The contribution of peripheral abnormalities to the disease's pathogenesis is not well understood.<h4>Methods</h4>To investigate this, we employed a multi-omics approach analyzing blood samples from 52 NMOSD patients and 46 healthy controls (HC). This included mass cytometry, cytokine arrays, and targeted metabolomics. We then analyzed the peripheral changes of NMOSD, and features related to NMOSD's disease severity. Furthermore, an integrative analysis was conducted to identify the distinguishing characteristics of NMOSD from HC. Additionally, we unveiled the variations in peripheral features among different clinical subgroups within NMOSD. An independent coJournal of translational medicineIntegrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders.PMC1152932282201558LG202101-01-01SYS20220581821005Ge CZhou QLuo ZZhang JXie ZFeng YChu XHe LYang DLi LGeng MLiu XYang XDu CHu JZhang XSun GChen SMeng HfalseIntegrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders.<h4>Background</h4>Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The contribution of peripheral abnormalities to the disease's pathogenesis is not well understood.<h4>Methods</h4>To investigate this, we employed a multi-omics approach analyzing blood samples from 52 NMOSD patients and 46 healthy controls (HC). This included mass cytometry, cytokine arrays, and targeted metabolomics. We then analyzed the peripheral changes of NMOSD, and features related to NMOSD's disease severity. Furthermore, an integrative analysis was conducted to identify the distinguishing characteristics of NMOSD from HC. Additionally, we unveiled the variations in peripheral features among different clinical subgroups within NMOSD. An independent co2024-01-01T00:00:00Z2024 Nov2025-04-04T13:20:03.707Z2025-04-04T13:20:03.707ZS-EPMC115293223948754610.1186/s12967-024-05801-8