biostudies-literatureShangguan FNatural Science Foundation of Hunan ProvinceNational Natural Science Foundation of Chinae084815https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529581biostudies-literatureUnknown14(10)<h4>Introduction</h4>Women with polycystic ovary syndrome (PCOS) experience various metabolic, endocrine, reproductive and psychosocial manifestations. Lifestyle modification is crucial for the management of PCOS to reduce long-term complications. Nonetheless, the efficacy and acceptability of lifestyle interventions differs, and there are no uniform methods of clinical application. Hence, a systematic review and network meta-analysis (NMA) are needed to explore the efficacy and acceptability of lifestyle interventions to inform clinical practice.<h4>Methods and analysis</h4>Ten databases (Cochrane Gynaecology and Fertility Specialised Register, Cochrane Register of Studies Online, PubMed, EMBASE (Excerpta Medica Database), PsycINFO, CINAHL (Cumulative Index to Nursing and Allied Health LiBMJ openEffectiveness and acceptability of different lifestyle interventions for women with polycystic ovary syndrome: protocol for a systematic review and network meta-analysis.PMC1152958182272383320701892024JJ5349Liu HLi ZGuo YLiang YShangguan FYu JSu YYu HfalseEffectiveness and acceptability of different lifestyle interventions for women with polycystic ovary syndrome: protocol for a systematic review and network meta-analysis.<h4>Introduction</h4>Women with polycystic ovary syndrome (PCOS) experience various metabolic, endocrine, reproductive and psychosocial manifestations. Lifestyle modification is crucial for the management of PCOS to reduce long-term complications. Nonetheless, the efficacy and acceptability of lifestyle interventions differs, and there are no uniform methods of clinical application. Hence, a systematic review and network meta-analysis (NMA) are needed to explore the efficacy and acceptability of lifestyle interventions to inform clinical practice.<h4>Methods and analysis</h4>Ten databases (Cochrane Gynaecology and Fertility Specialised Register, Cochrane Register of Studies Online, PubMed, EMBASE (Excerpta Medica Database), PsycINFO, CINAHL (Cumulative Index to Nursing and Allied Health Li2024-01-01T00:00:00Z2024 Oct2026-07-16T07:01:44.106Z2025-04-04T01:58:39.542ZS-EPMC115295813947727010.1136/bmjopen-2024-084815