{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ihara K"],"funding":["Renalytix Inc","Novo Nordisk","NIDDK NIH HHS","National Institutes of Health"],"pagination":["e178373"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529980"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(20)"],"pubmed_abstract":["Many circulating proteins are associated with risk of ESKD, but their source and the biological pathways/disease processes they represent are unclear. Using OLINK proteomics platform, concentrations of 455 proteins were measured in plasma specimens obtained at baseline from 399 individuals with diabetes. Elevated concentrations of 46 circulating proteins were associated (P < 1 × 10-5) with development of ESKD (n = 143) during 7-15 years of follow-up. Twenty of these proteins enriched apoptosis/TNF receptor signaling pathways. A subset of 20 proteins (5-7 proteins), summarized as an apoptosis score, together with clinical variables accurately predicted risk of ESKD. Expression of genes encoding the 46 proteins in peripheral WBCs showed no difference between cells from individuals who did or"],"journal":["JCI insight"],"pubmed_title":["Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes."],"pmcid":["PMC11529980"],"funding_grant_id":["NA","NNF14OC0013659","R01 DK041526","R01 DK123459","P30 DK036836","R01 DK126799","DK041526,DK110350,DK126799,DK123459,DK131915,DK036836","R01 DK131061","R01 DK110350","R33 DK131915","R61 DK131915"],"pubmed_authors":["Satake E","Niewczas MA","Nelson RG","Duffin K","Doria A","Wilson J","Kobayashi H","Pezzolesi MG","Krolewski AS","Wilson PC","Krolewski B","Humphreys BD","Ihara K","Ricca J","Md Dom ZI","Dreyfuss JM"],"additional_accession":[]},"is_claimable":false,"name":"Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes.","description":"Many circulating proteins are associated with risk of ESKD, but their source and the biological pathways/disease processes they represent are unclear. Using OLINK proteomics platform, concentrations of 455 proteins were measured in plasma specimens obtained at baseline from 399 individuals with diabetes. Elevated concentrations of 46 circulating proteins were associated (P < 1 × 10-5) with development of ESKD (n = 143) during 7-15 years of follow-up. Twenty of these proteins enriched apoptosis/TNF receptor signaling pathways. A subset of 20 proteins (5-7 proteins), summarized as an apoptosis score, together with clinical variables accurately predicted risk of ESKD. Expression of genes encoding the 46 proteins in peripheral WBCs showed no difference between cells from individuals who did or","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-05-04T06:39:26.676Z","creation":"2025-04-06T09:35:12.468Z"},"accession":"S-EPMC11529980","cross_references":{"pubmed":["39435665"],"doi":["10.1172/jci.insight.178373"]}}