{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eaton-Fitch N"],"funding":["Blake Beckett Trust Foundation","The Stafford Fox Medical Research Foundation","Ian and Talei Stewart","Buxton Foundation","Henty Lions Club","Alison Hunter Memorial Foundation","National Health and Medical Research Council","Change for ME Charity","Mason Foundation","McCusker Charitable Foundation","Henty Community"],"pagination":["e183810"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11529985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(20)"],"pubmed_abstract":["Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune dysregulation and cellular signaling pathways contributing to the pathophysiology. In this study, immune exhaustion gene expression was investigated in participants with ME/CFS or long COVID concurrently. RNA was extracted from peripheral blood mononuclear cells isolated from participants with ME/CFS (n = 14), participants with long COVID (n = 15), and healthy controls (n = 18). Participants with ME/CFS were included according to Canadian Consensus Criteria. Participants with long COVID were eligible according to the case definition for \"Post COVID-19 Condition\" published by the World Health Organization. RNA was analyzed using the NanoString n"],"journal":["JCI insight"],"pubmed_title":["Immune exhaustion in ME/CFS and long COVID."],"pmcid":["PMC11529985"],"funding_grant_id":["49979","4570","47107","4880","4575","4676","489798","00000","1199502","4579","4879"],"pubmed_authors":["Er T","Marshall-Gradisnik S","Eaton-Fitch N","Herrero L","Hool L","Rudd P"],"additional_accession":[]},"is_claimable":false,"name":"Immune exhaustion in ME/CFS and long COVID.","description":"Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune dysregulation and cellular signaling pathways contributing to the pathophysiology. In this study, immune exhaustion gene expression was investigated in participants with ME/CFS or long COVID concurrently. RNA was extracted from peripheral blood mononuclear cells isolated from participants with ME/CFS (n = 14), participants with long COVID (n = 15), and healthy controls (n = 18). Participants with ME/CFS were included according to Canadian Consensus Criteria. Participants with long COVID were eligible according to the case definition for \"Post COVID-19 Condition\" published by the World Health Organization. RNA was analyzed using the NanoString n","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-04-07T16:05:56.006Z","creation":"2025-04-06T23:17:01.336Z"},"accession":"S-EPMC11529985","cross_references":{"pubmed":["39435656"],"doi":["10.1172/jci.insight.183810"]}}