biostudies-literatureLei ZLuzhou Center for Disease Control and Prevention ResearchSouthwest Medical University ResearchLuzhou Science and Technology Program26357https://www.ebi.ac.uk/biostudies/studies/S-EPMC11530645biostudies-literatureUnknown14(1)This study examines the factors influencing COVID-19 vaccination intentions among Chinese residents over the age of 60, with a focus on the mediating roles of Health Beliefs and Cues to Vaccination Action in the relationship between vaccine knowledge and vaccination intentions. We conducted a cross-sectional online survey involving 1,305 participants from Southwest China. Multiple logistic regression analysis identified potential determinants of vaccination intention, including socioeconomic characteristics, knowledge, health beliefs, and cues to vaccination action. Furthermore, mediation analysis using the causal mediation analysis method explored the mediating effects within the knowledge-to-intention pathway. Vaccination intention and its related factors: among the 1212 elderly people iScientific reportsFactors influencing COVID-19 vaccination intentions and mediating effects among older adults in Southwest China.PMC115306452021-ZRK-1232023XGZX016LZCDC2024ZD-02Lei ZChen LWang XChen HLiu DDing ZChang YFan SfalseFactors influencing COVID-19 vaccination intentions and mediating effects among older adults in Southwest China.This study examines the factors influencing COVID-19 vaccination intentions among Chinese residents over the age of 60, with a focus on the mediating roles of Health Beliefs and Cues to Vaccination Action in the relationship between vaccine knowledge and vaccination intentions. We conducted a cross-sectional online survey involving 1,305 participants from Southwest China. Multiple logistic regression analysis identified potential determinants of vaccination intention, including socioeconomic characteristics, knowledge, health beliefs, and cues to vaccination action. Furthermore, mediation analysis using the causal mediation analysis method explored the mediating effects within the knowledge-to-intention pathway. Vaccination intention and its related factors: among the 1212 elderly people i2024-01-01T00:00:00Z2024 Nov2026-07-16T07:04:33.874Z2025-04-04T01:02:45.006ZS-EPMC115306453948721410.1038/s41598-024-76437-3