biostudies-literatureKim JSMinistry of Education, Science and TechnologyKorea Ministry of Science and ICTNational Research Foundation of Korea100953https://www.ebi.ac.uk/biostudies/studies/S-EPMC11530836biostudies-literatureUnknown19(5)While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs, enabling the fabrication of nanoparticles with fine and uniform particle size distribution. Regorafenib (1 g), as a model drug, copovidone (5 g), and sodium dodecyl sulfate (0.1 g) were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray dryer. The electrostatic spray-dried nanoparticles (ESDN) showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles (CSDN). ESDN Asian journal of pharmaceutical sciencesElectrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs.PMC11530836RS-2023-002084482022R1A2C2004197RS-2024-00407053Kim JOJin SGChoi HGChung JEWoo MRNguyen BLLim SJCheon SKim JSWoo SKu SKOh KTYoun YSfalseElectrostatic spraying for fine-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs.While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs, enabling the fabrication of nanoparticles with fine and uniform particle size distribution. Regorafenib (1 g), as a model drug, copovidone (5 g), and sodium dodecyl sulfate (0.1 g) were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray dryer. The electrostatic spray-dried nanoparticles (ESDN) showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles (CSDN). ESDN 2024-01-01T00:00:00Z2024 Oct2026-07-16T09:34:00.781Z2025-04-04T01:02:29.648ZS-EPMC115308363949380610.1016/j.ajps.2024.100953