{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Wang J"],"pubmed_abstract":["<i>Brucella abortus</i> (<i>B.abortus</i>) is a zoonotic bacterial pathogen that causes chronic host infections. The eradication of brucellosis using antibiotic therapy is often incomplete or slow. In a mouse model, the predominance of alternatively activated macrophages (also known as M2) plays an essential role in sustaining chronic infection. The underlying functional mechanism by which M2 sustains chronic infection remains unclear. Here, we show that <i>B. abortus</i> can enter M2 via triggering receptor expressed on myeloid cells 2 (TREM2) and promotes the upregulation of TREM2 expression of M2 in a type IV secretion system (T4SS)-dependent manner. Increased TREM2 enhances <i>B. abortus</i> growth within M2 by suppressing intracellular ROS production, preventing M2 pyroptosis via supp"],"journal":["Frontiers in immunology"],"pagination":["1466520"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11532147"],"repository":["biostudies-literature"],"pubmed_title":["Upregulation of TREM2 expression in M2 macrophages promotes <i>Brucella abortus</i> chronic infection."],"pmcid":["PMC11532147"],"pubmed_authors":["Zhang W","Liu X","Yan Z","Peng Q","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Upregulation of TREM2 expression in M2 macrophages promotes <i>Brucella abortus</i> chronic infection.","description":"<i>Brucella abortus</i> (<i>B.abortus</i>) is a zoonotic bacterial pathogen that causes chronic host infections. The eradication of brucellosis using antibiotic therapy is often incomplete or slow. In a mouse model, the predominance of alternatively activated macrophages (also known as M2) plays an essential role in sustaining chronic infection. The underlying functional mechanism by which M2 sustains chronic infection remains unclear. Here, we show that <i>B. abortus</i> can enter M2 via triggering receptor expressed on myeloid cells 2 (TREM2) and promotes the upregulation of TREM2 expression of M2 in a type IV secretion system (T4SS)-dependent manner. Increased TREM2 enhances <i>B. abortus</i> growth within M2 by suppressing intracellular ROS production, preventing M2 pyroptosis via supp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-16T09:31:54.287Z","creation":"2025-04-04T07:28:11.284Z"},"accession":"S-EPMC11532147","cross_references":{"pubmed":["39497817"],"doi":["10.3389/fimmu.2024.1466520"]}}