{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao E"],"funding":["the Science and Technology Program of Guangzhou","the Natural Science Foundation of Guangdong Province","the National Natural Science Foundation of China"],"pagination":["392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11533353"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury (DILI). N-acetylcysteine (NAC) is the first-line agent used in the clinic. However, it rarely benefits patients with advanced APAP toxicity. Mesenchymal stromal cells (MSCs) have demonstrated potential in treating DILI. However, the specific mechanism by which MSCs protect against APAP-induced liver injury remains unclear.<h4>Methods</h4>APAP was injected intraperitoneally to induce a liver injury model. We then detected histopathology, biochemical indices, and inflammatory cytokine levels to assess the efficacy of MSCs and MSC extracellular vesicles (MSC-EVs). Flow cytometry was performed to reveal the immunoregulatory effects of MSCs and MSC-EVs on the neutrophils. RNA sequencing (RNA-Seq"],"journal":["Stem cell research & therapy"],"pubmed_title":["Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p/CXCL1 axis."],"pmcid":["PMC11533353"],"funding_grant_id":["2022A1515012223","81971526 and 82370629","202201020398, 202201020430"],"pubmed_authors":["Tan W","Zhang Y","Li P","Lu D","Qin Y","Liu Q","Zhao E","Chen S","Zhang Q","Liang R"],"additional_accession":[]},"is_claimable":false,"name":"Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p/CXCL1 axis.","description":"<h4>Background</h4>Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury (DILI). N-acetylcysteine (NAC) is the first-line agent used in the clinic. However, it rarely benefits patients with advanced APAP toxicity. Mesenchymal stromal cells (MSCs) have demonstrated potential in treating DILI. However, the specific mechanism by which MSCs protect against APAP-induced liver injury remains unclear.<h4>Methods</h4>APAP was injected intraperitoneally to induce a liver injury model. We then detected histopathology, biochemical indices, and inflammatory cytokine levels to assess the efficacy of MSCs and MSC extracellular vesicles (MSC-EVs). Flow cytometry was performed to reveal the immunoregulatory effects of MSCs and MSC-EVs on the neutrophils. RNA sequencing (RNA-Seq","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-02T22:13:15.759Z","creation":"2025-04-06T14:25:56.824Z"},"accession":"S-EPMC11533353","cross_references":{"pubmed":["39490995"],"doi":["10.1186/s13287-024-03995-8"]}}