{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Ly M"],"pubmed_abstract":["<h4>Introduction</h4>Brain age is a machine learning-derived estimate that captures lower brain volume. Previous studies have found that brain age is significantly higher in mild cognitive impairment and Alzheimer's disease (AD) compared to healthy controls. Few studies have investigated changes in brain age longitudinally in MCI and AD. We hypothesized that individuals with MCI and AD would show heightened brain age over time and across the lifespan. We also hypothesized that both MCI and AD would show faster rates of brain aging (higher slopes) over time compared to healthy controls.<h4>Methods</h4>We utilized data from an archival dataset, mainly Alzheimer's disease Neuroimaging Initiative (ADNI) 1 with 3Tesla (3 T) data which totaled 677 scans from 183 participants. This constitutes a "],"journal":["Frontiers in aging neuroscience"],"pagination":["1433426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11534682"],"repository":["biostudies-literature"],"pubmed_title":["Longitudinal accelerated brain age in mild cognitive impairment and Alzheimer's disease."],"pmcid":["PMC11534682"],"pubmed_authors":["Alzheimer’s disease Neuroimaging Initiative","Son SJ","Pascoal T","Yu G","Karim HT","Ly M"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal accelerated brain age in mild cognitive impairment and Alzheimer's disease.","description":"<h4>Introduction</h4>Brain age is a machine learning-derived estimate that captures lower brain volume. Previous studies have found that brain age is significantly higher in mild cognitive impairment and Alzheimer's disease (AD) compared to healthy controls. Few studies have investigated changes in brain age longitudinally in MCI and AD. We hypothesized that individuals with MCI and AD would show heightened brain age over time and across the lifespan. We also hypothesized that both MCI and AD would show faster rates of brain aging (higher slopes) over time compared to healthy controls.<h4>Methods</h4>We utilized data from an archival dataset, mainly Alzheimer's disease Neuroimaging Initiative (ADNI) 1 with 3Tesla (3 T) data which totaled 677 scans from 183 participants. This constitutes a ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T18:54:50.966Z","creation":"2025-04-04T18:54:50.966Z"},"accession":"S-EPMC11534682","cross_references":{"pubmed":["39503045"],"doi":["10.3389/fnagi.2024.1433426"]}}